Pathways enriched in genes significantly altered by AP5
| Rank | p value | Ratio | Pathway | Synapse | Apoptosis | HDAC |
|---|---|---|---|---|---|---|
| 1 | 2.44E-10 | 27:65 | Cardiac hypertrophy–NF-AT signaling in cardiac hypertrophy | Y | ||
| 2 | 7.08E-10 | 28:72 | Reproduction–GnRH signaling | Y | ||
| 3 | 1.75E-08 | 22:54 | Development–role of HDAC and CaMK in control of skeletal myogenesis | Y | ||
| 4 | 1.33E-07 | 23:64 | Development–regulation of EMT | |||
| 5 | 2.10E-07 | 26:80 | Neurophysiological process–NMDA-dependent postsynaptic LTP in CA1 hippocampal neurons | Y | ||
| 6 | 2.16E-06 | 30:111 | Cytoskeleton remodeling–TGF, WNT, and cytoskeletal remodeling | |||
| 7 | 2.61E-06 | 17:45 | Neurophysiological process–glutamate regulation of dopamine D1A receptor signaling | Y | ||
| 8 | 3.00E-06 | 18:50 | Immune response–Function of MEF2 in T lymphocytes | Y | ||
| 9 | 3.62E-06 | 15:37 | Development–MAG-dependent inhibition of neurite outgrowth | |||
| 10 | 4.03E-06 | 14:33 | Apoptosis and survival–caspase cascade | Y | ||
| 11 | 4.16E-06 | 18:51 | Signal transduction–PKA signaling | |||
| 12 | 6.16E-06 | 14:34 | Development–role of CDK5 in neuronal development | |||
| 13 | 6.37E-06 | 11:22 | Development–thrombopoetin signaling via JAK–STAT pathway | |||
| 14 | 6.48E-06 | 16:43 | Apoptosis and survival–FAS signaling cascades | Y | ||
| 15 | 6.90E-06 | 11:26 | Immune response–IL-10 signaling pathway | |||
| 16 | 7.06E-06 | 27:100 | Cell adhesion–chemokines and adhesion | |||
| 17 | 7.76E-06 | 18:53 | Apoptosis and survival–endoplasmic reticulum stress response pathway | Y | ||
| 18 | 1.00E-05 | 17:49 | Development–PEDF signaling | |||
| 19 | 1.28E-05 | 16:45 | Neurophysiological process–Receptor-mediated axon growth repulsion | |||
| 20 | 1.36E-05 | 17:50 | Development–GM-CSF signaling | |||
| 21 | 2.28E-05 | 12:32 | Apoptosis and survival–granzyme B signaling | Y |
The top enriched pathways are shown, ranked by p value (Fisher's exact test). The ratio shows the number of genes that were significantly altered by AP5 divided by the total number of genes in that specific pathway. EMT, Epithelial-to-mesenchymal transition; GnRH, gonadotropin-releasing hormone; PKA, protein kinase A; GM-CSF, granulocyte macrophage colony-stimulating factor; PEDF, pigment epithelium-derived factor; MAG, myelin-associated glycoprotein; MEF2, myocyte enhancer factor 2. Y indicates that the pathway is related to either Synpase, Apoptosis, or HDAC.