Table 5.

Human tissues and quantification of MAP1B in the cytoplasm of spinal cord motor neurons

CaseDiagnosisAge (years)/genderPMT (hours)Number of MNs countedPercentage of MNs with MAP1B in cell body
C1Control brain–no pathology54/M61480
C2Subacute infarcts53/F41621.8
C3Metastatic carcinoma51/F5650
C4Metastatic carcinoma57/F11280
C5Pulmonary fibrosis57/M21080
C6Control brain–no pathology58/F5620
ALS1ALS62/F43219
ALS2ALS50/F71030.0
ALS3Familial ALS (C9ORF72)63/F4350
ALS4ALS60/F44466
ALS5ALS59/M412172
ALS6ALS63/F25159
ALS7ALS53/M82552
ALS8ALS55/M33757
  • PMT, Postmortem interval; MN, motor neuron; M, male; F, female. The percentage of spinal cord motor neurons containing MAP1B in the cell body was determined in motor neurons observed in between two and four tissue sections per case. The average percentage of motor neurons containing MAP1B in the cell body was 0.3 ± 0.3% per control case and 44 ± 8.9% per ALS case (±SD).