TDP-43 expression alters Futsch protein localization
| D42>w1118 (absolute value; ratio to w1118 VG) | D42>TDPWT (absolute value; ratio to w1118) | D42>TDPG298S (absolute value; ratio to w1118) | |
|---|---|---|---|
| VG | 1.20 ± 0.07; 1.0 | 1.96 ± 0.15; 1.63 (p = 0.01) | 1.94 ± 0.16; 1.61 (p = 0.01) |
| NMJ | 1.72 ± 0.09; 1.4 | 0.92 ± 0.04; 0.53 (p = 0.001) | 0.96 ± 0.06; 0.56 (p = 0.001) |
Futsch protein levels normalized to actin at the ventral ganglia (VG) and NMJ. Genotypes are as indicated. Mean ± SEM and p values are as shown. See also Fig. 8. Western blots were performed as described in Materials and Methods.