List of genes deregulated by l-DOPA and blocked by SL-327
| Official gene symbol | Nucleotide universal identifier | l-DOPA vs saline (fold change) | l-DOPA + SL327 vs l-DOPA + vehicle (fold change) | Univariate p-value* | FDR* |
|---|---|---|---|---|---|
| FosB | Ere3vD3o.tqhOQ.x94 | +8.76 | −2.08 | 0.0075 | 0.021 |
| Arc | oyruyspXqhyohXojdA | +4.49 | −1.56 | 0.0196 | 0.036 |
| Nptx2 | BU2LP1VoHoj2ptP6ec | +4.09 | −1.87 | 0.0066 | 0.020 |
| Ccrn4l | ruOG_shu4I8dQ0fdeo | +3.95 | −1.22 | 0.0102 | 0.026 |
| Dgki | ZnFK.QqcSo7EEoRjJU | +3.69 | −1.22 | 0.0325 | 0.048 |
| Nedd4l | ESdC5ZVdFlD3Qevluw | +3.21 | −1.34 | 0.0003 | 0.003 |
| Car12 | re1dJUylHuMPt50k.U | +2.84 | −1.25 | 0.0020 | 0.010 |
| C8b | HERI41YuB1BXREfJSk | +2.62 | −1.53 | 0.0239 | 0.041 |
| Zfp280d | uLS7MJ7kgVRdJVTgcs | +2.48 | −1.26 | 0.0406 | 0.058 |
| Ippk | idcnpHiD3Gq0Ugu5ek | +2.43 | −1.37 | 5.29E-05 | 0.002 |
| Th | Ko4nkRXhUJHi5TycDk | +2.32 | −1.40 | 0.0290 | 0.046 |
| Dmkn | 3akQXpeeC6eC0.6yBPU | +2.20 | −1.36 | 0.0049 | 0.018 |
| Dmkn | Nmh10YORErfSov4e18 | +2.03 | −1.33 | 0.0040 | 0.016 |
| Kcnk1 | 6VF0RwJEOktVd1XgSM | +1.66 | −1.20 | 0.0002 | 0.003 |
| Agpat1 | NI5Q.efVXJdFXlUrLo | +1.62 | −1.23 | 0.0315 | 0.048 |
| Mocs1 | creVEXtx3pO7SgCibQ | −2.72 | +1.22 | 0.0007 | 0.005 |
| Mef2c | 9r_hIVpC64cWsPsoEY | −2.49 | +1.28 | 0.0040 | 0.016 |
| Gm10762 | KlFvB5mECAoFSh6a0.0 | −2.47 | +1.49 | 0.0157 | 0.032 |
| Pa2g4 | EpeAOAH0bl0.9LiugaY | −2.33 | +1.21 | 0.0245 | 0.041 |
| Bbc3 | uioaVJewjHsTkeeyMw | −2.30 | +1.36 | 0.0155 | 0.032 |
| Ganc | 3qeocgyRKj6R_3ykYU | −2.26 | +1.26 | 0.0003 | 0.003 |
| Hecw1 | 3TeO9EhFExAnkiRjrk | −2.17 | +1.63 | 0.0013 | 0.008 |
| Arrb2 | fladaeCoOCjjh7jhS8 | −2.12 | +1.23 | 0.0016 | 0.009 |
| Cln6 | Ed_ISRN0l4N3RReXrk | −2.07 | +1.32 | 0.0188 | 0.036 |
| Syt12 | TrSLz4qjZNMbiuentE | −1.92 | +1.22 | 0.0057 | 0.019 |
| Tusc1 | HpdSI3.yLN94SuOP4k | −1.76 | +1.27 | 0.0122 | 0.029 |
| Vstm2a | 3.EkJQO7FbNLDvRTn4 | −1.58 | +1.22 | 0.0102 | 0.026 |
| 3632451O06Rik | oPE5K3u7N_TwP9SXfs | −1.38 | +1.22 | 0.0160 | 0.032 |
List of the 28 probes deregulated by l-DOPA (our first experiment, 709 probes) for which SL327 pretreatment significantly reduced the effects of l-DOPA (that could be increase or decrease) (>1.2-fold, p < 0.05, FDR < 0.1). The fold changes of expression induced 3 h after l-DOPA in the first experiment (compared with T0, left column) and 3 h after l-DOPA + SL327 (compared with l-DOPA + vehicle, right column) are presented.
↵* p-values and FDR values for the comparison of gene expression between l-DOPA + SL327 and l-DOPA + vehicle.