Table 1.

Mice analyzed in different experiments

	Figure	Mice per group	Total no.	From cohort(s)	Age at analysis
Longevity
	2B	NTG, 111	366 mice	A–H	3 weeks to 12.5 months
		hAPP, 67
		KL, 110
		hAPP/KL, 78
EEG
	2D	NTG, 3	21 mice	B	2–3.5 months
		KL, 4
		hAPP, 7
		hAPP/KL, 7
Behavior
Water maze	3A–C	NTG, 14	63 mice	B, C	4–7 months
		KL, 14
		hAPP, 18
		hAPP/KL, 17
Novel object	3D	NTG, 10	45 mice	C	5–8 months
		KL, 11
		hAPP, 12
		hAPP/KL, 12
Passive avoidance	3E	NTG, 23	72 mice	C	5–8 months
		KL, 21
		hAPP, 15
		hAPP/KL, 13
Open field, elevated plus maze	3F, G	NTG, 24	81 mice	C	4–7 months
		KL, 21
		hAPP, 20
		hAPP/KL, 16
Biochemistry/histology
Western	1	NTG, 10	23 mice	D	5–7 months
Western	1	hAPP, 13	23 mice	D	5–7 months
Western	2A, 6B–F, 7B, C	NTG, 14–15	43–45 mice	E	3 months
		KL, 13
		hAPP, 7–8
		hAPP/KL, 9
Westerns, Aβ ELISA	4B, E, K, L	hAPP, 7–8	15–17 mice	E	3 months
Westerns, Aβ ELISA	4B, E, K, L	hAPP/KL, 8–9	15–17 mice	E	3 months
Aβ oligomer ECL assay	4F	hAPP, 4	8 mice	F	3–4.5 months
Aβ oligomer ECL assay	4F	hAPP/KL, 4	8 mice	F	3–4.5 months
Western	4D	hAPP, 4	8 mice	F	3–4.5 months
		hAPP/KL, 4	8 mice	F	3–4.5 months
Immunohistochemistry	4H, J	hAPP, 12–13	21 mice	C	10–12.5 months
Immunohistochemistry	4H, J	hAPP/KL, 8–9	21 mice	C	10–12.5 months
Immunohistochemistry	5B, C	NTG, 25	75 mice	C	10–12.5 months
		KL, 27
		hAPP, 14
		hAPP/KL, 9
Electrophysiology
EPSP (LTP)	8A, B	NTG 3 slices/3 mice	23 slices, 16 mice	G	3.5–4.5 months
		KL 6 slices/5 mice
		hAPP 7 slices/5 mice
		hAPP/KL 7 slices/3 mice
fEPSP (I/O curves)	8C	NTG 9 slices/3 mice	39 slices, 16 mice	H	3.5–4.5 months
		KL 10 slices/5 mice
		hAPP 9 slices/5 mice
		hAPP/KL 11 slices/3 mice

Cohorts are independent groups of mice, some or all of which were analyzed at one or more time points/ages in one or more paradigms.