Table 2.

Significantly downregulated genes in the spinal cord of TCF7l2 cKO (Olig2–CreERT2, Tcf7l2fl/fl) compared with Tcf7l2fl/fl controls from gene array analysis

Gene symbolFold down
Opalin3.5
Casr3.0
9630013A20Rik2.7
Alox52.7
Tmem1412.5
Gm30882.4
Erbb32.4
Mag2.3
Tmem22.3
Gm194392.2
Parvb2.1
Mobp2.1
Trim592.1
Gm982.0
Mog2.0
Fa2 h2.0
Adamts42.0
Ccnyl12.0
Man1a2.0
Tmem88b2.0
Plekha11.9
Il23a1.9
Sytl21.9
Aspa1.9
Plekhh11.9
Gsn1.9
1700047M11Rik1.9
Cldn111.9
Secisbp2l1.9
Peli11.9
Otud7b1.9
Slc12a21.8
2810468N07Rik1.8
Gjc21.8
Anln1.8
Plekhg31.8
Ugt8a1.8
Plat1.8
Sh3gl31.8
Tmem1231.8
Jam31.8
Rasgef1b1.8
C030030A07Rik1.7
Ldlrap11.7
Stxbp3a1.7
Snx301.3
Taf10 Ilk1.3
Lgi31.3
Pip4k2a1.3
LOC1008618311.3
Ipo131.3
Fbxo81.3
Degs11.3
Stk391.3
Plekhb11.3
Ube2g11.3
Pop41.3
Tbc1d51.3
Pi4kb1.3
Me11.2
Mtap71.7
Gltp1.7
Elovl11.7
Tprn1.7
Cnp1.7
Dhcr241.7
Lass21.7
Rhog1.7
Ninj21.7
Olig21.7
Rap1a1.7
Hspa21.7
Tspan151.7
Syde21.6
Zdhhc91.6
Sema4d1.6
Tmem1251.6
Hapln21.6
Ppp1r14a1.6
1500015L24Rik1.6
Tspan21.6
Klhl21.6
Arhgef101.6
Tns31.6
Dock101.6
Tmem1821.6
Piga1.6
Plekhg11.6
Strn1.6
Carhsp11.6
Atp8b11.6
Idh11.6
Tppp1.6
Adipor21.6
Nfasc1.6
Il1rap1.6
Ddc1.5
Gss1.5
Mal1.5
Gab11.5
Rab33a1.5
Kndc11.5
Stx21.5
Gramd31.5
Sorbs31.5
Foxn31.2
Hipk21.2
Erf1.2
Atp6v1g11.2
D15Ertd621e1.2
AW5498771.2
Lpar31.2
Ltv11.2
Aatk1.2
Nudt41.2
Pim31.2
Nkain21.2
Acsl3 Utp14b1.2
Csrp11.2
Txndc161.2
St181.5
Mcam1.5
Nkx6–21.5
Dbndd21.5
Tmem63a1.5
6330503K22Rik1.5
Klhl41.5
Sc5d1.5
Snx181.5
Fbxo321.5
Ppp1r16b1.5
Dusp151.5
Ypel21.5
Rffl1.5
Smad71.5
Kif19a1.5
G2e31.5
Rcbtb11.5
Apod1.5
Enpp21.4
Sox21.4
Cyp511.4
Ctnnal11.4
Npc11.4
Ephb11.4
Pex5l1.4
Fmnl21.4
Il12rb11.4
Hhip1.4
Gm195001.4
Slc44a11.4
Sox101.4
Map4k41.4
Kat2b1.4
Reep31.4
Ick1.4
Rab311.4
Enpp41.4
Zfp5361.4
Nde11.4
Ankrd13a1.4
Fntb LOC6395411.4
Ado1.4
Acy31.4
Chmp1b1.4
Ctnna11.2
Aplp11.2
Lamp11.2
Ktn11.2
Creb51.2
Prrg11.2
Eps151.2
Ankib11.2
Picalm1.2
Mmgt11.2
Cap11.2
Dock91.2
Fth11.2
Polr1d1.2
Fkbp1a1.2
Sirt21.4
Creb3l21.4
Ptpn111.4
Prickle11.4
Rtkn1.4
Ptpdc11.4
Npat1.4
Cpd1.4
Fgfr21.4
Cdk191.4
Acsl11.4
Bace11.4
Mbp1.4
Sypl1.4
Dram21.4
Fam108b1.4
Gm114921.4
Eif2c31.4
Npc21.4
Bin11.4
Gjb11.3
Cyp3a131.3
Rnf131.3
Setd81.3
Nkain11.3
Evi2a Evi2b1.3
Ankrd491.3
Smurf11.3
Erbb2ip1.3
Phactr41.3
Tmem1631.3
Mospd21.3
Qk1.3
2810008M24Rik1.3
Entpd51.3
Rock11.3
Ralgds1.3
+Papss11.3
Gm198971.3
Myo61.3
Mtmr21.3
Rap2a1.3
Arap21.3
Snap231.3
Twf1 Gm48871.3
Tbc1d141.2
Srd5a11.2
Lrrn11.2
Slc22a231.2
Dhrs71.2
Gclm1.2
Rhbdl21.2
Ncor21.2
Kif5b1.2
Rhoa1.2
Mtmr61.2
Gm4281.2
Add11.2
Plp11.2
Frmd4a1.2
  • TCF7l2 was conditionally ablated in mice by tamoxifen injection at P6 and P7 (1 injection per day), and spinal cord tissue was harvested on P14. n = 4 in each group, p < 0.05 with false discovery rate correction. Only genes with a minimal downregulation of 1.2-fold in Olig2–CreERT2, Tcf7l2fl/fl mice are shown here. Genes marked in bold are myelin genes or genes known to regulate OL differentiation.