Table 2.

Effect of intra-DRN baclofen on aggressive and nonaggressive behaviors in 5-HTT−GABAB1−/− (cKO) mice

aCSFBaclofen 0.06 nmolBaclofen 0.3 nmol
Attack bites
    WT20.5 ± 2.932.9 ± 3.643.9 ± 7.3*
    cKO15.7 ± 2.741.2 ± 7.9*34.5 ± 6.5*
Sideways threats (s)
    WT12.0 ± 1.823.8 ± 3.5*24.8 ± 5.8*
    cKO8.8 ± 2.028.8 ± 6.5*21.6 ± 5.8
Tail rattles (s)
    WT18.0 ± 3.733.1 ± 7.337.6 ± 9.0
    cKO11.8 ± 3.427.2 ± 6.6*32.9 ± 7.4*
Pursuits (s)
    WT6.7 ± 2.610.3 ± 2.926.6 ± 9.7*
    cKO4.7 ± 2.315.2 ± 5.115.9 ± 4.8
Walking (s)
    WT73.5 ± 5.574.9 ± 7.8113.1 ± 19.9
    cKO80.5 ± 5.772.0 ± 6.6125.5 ± 21.9
Rearing (s)
    WT16.3 ± 3.311.5 ± 3.37.3 ± 2.3
    cKO19.8 ± 3.913.1 ± 4.19.1 ± 3.0
Self-grooming (s)
    WT29.2 ± 8.728.2 ± 4.914.1 ± 4.8
    cKO32.2 ± 7.523.5 ± 4.712.8 ± 3.9*
Social contact (s)
    WT22.0 ± 8.515.9 ± 3.920.3 ± 7.5
    cKO18.2 ± 4.814.3 ± 3.620.4 ± 4.8
  • All values are mean ± SEM;

  • *p < 0.05 compared with aCSF.