Physiological variables for Sprague Dawley 211 rats during electrophysiological experiments after IH-1 and normoxia with AIH or time control and systemic treatment with ketoprofen (keto)
| Time | Treatment group | Temperature | PaO2 | PaCO2 | pH | MAP |
|---|---|---|---|---|---|---|
| Baseline | Time control | 37.2 ± 0.1 | 342 ± 5 | 43 ± 2 | 7.380 ± 0.010 | 102 ± 4### |
| Nx, keto + AIH | 37.4 ± 0.1 | 325 ± 13 | 44 ± 1 | 7.376 ± 0.006 | 110 ± 5 | |
| IH-1, keto + AIH | 37.4 ± 0.1 | 340 ± 5 | 43 ± 1 | 7.365 ± 0.009 | 116 ± 3 | |
| Hx | Time control | 37.3 ± 0.1 | 339 ± 4* | 43 ± 2 | 7.381 ± 0.010 | 102 ± 3* |
| Nx, keto + AIH | 37.3 ± 0.1 | 37 ± 2** | 44 ± 1 | 7.367 ± 0.010 | 55 ± 5** | |
| IH-1, keto + AIH | 37.4 ± 0.1 | 37 ± 1** | 42 ± 1 | 7.354 ± 0.010## | 54 ± 3** | |
| 60 min | Time control | 37.3 ± 0.1 | 330 ± 4 | 43 ± 2 | 7.389 ± 0.010 | 100 ± 4 |
| Nx, keto + AIH | 37.4 ± 0.1 | 296 ± 11*,*** | 44 ± 1 | 7.376 ± 0.010 | 104 ± 4 | |
| IH-1, keto + AIH | 37.4 ± 0.2 | 327 ± 8 | 44 ± 1# | 7.376 ± 0.006 | 107 ± 6 |
↵*p < 0.001 (difference from all other groups within time point);
↵**p < 0.001 (difference from other time points within group);
↵***p < 0.01 (difference from baseline within group);
↵#p < 0.05 (difference from other time points within group);
↵##p < 0.01 (different from other time points within group);
↵###p < 0.05 (difference from IH-1, keto + AIH within time point). Hx, Hypoxia; MAP, mean arterial pressure.