Table 1.

Metabolite concentrations, CRLB, linewidths, and voxel tissue composition

Subcortical voxelFrontal voxel
<25 years>25 years<25 years>25 years
n (n females)51 (25)29 (15)28 (15)28 (15)
Age15.1 (4.8)35.6 (8.9)18.5 (3.5)35.6 (9.1)
MEGA-PRESS
    GABA+/H2O (mm)1.9 (0.2)1.9 (0.2)1.4 (0.1)1.5 (0.2)
    GABA+/H2O CRLB (%)3.5 (0.6)3.9 (1.0)4.6 (0.9)4.4 (0.9)
    Glu/H2O (mm)4.2 (0.5)3.7 (0.5)3.7 (0.4)3.7 (0.3)
    Glu/H2O CRLB (%)4.1 (1.0)5.3 (1.9)3.8 (1.2)4.0 (0.9)
    Gln/H2O (mm)*1.3 (0.5)1.7 (0.7)1.0 (0.3)1.1 (0.3)
    Gln/H2O CRLB (%)*15.3 (2.8)16.2 (2.1)13.9 (3.1)14.4 (2.7)
    NAA/H2O (mm)8.9 (0.5)9.1 (0.5)8.2 (0.4)8.4 (0.4)
    NAA/H2O CRLB (%)1.0 (0.3)1.0 (0.2)1.1 (0.3)1.1 (0.3)
PRESS
    Cr/H2O (mm)5.3 (0.9)5.2 (0.6)5.0 (0.5)5.4 (0.3)
    Cr/H2O CRLB (%)1.9 (0.2)2.0 (0.3)2.0 (0.2)1.9 (0.3)
    Cho/H2O (mm)0.6 (0.1)0.6 (0.1)0.7 (0.1)0.7 (0.1)
    Cho/H2O CRLB (%)2.2 (0.4)2.3 (0.5)2.1 (0.3)2.1 (0.3)
Linewidth (Hz)8.0 (2.2)9.4 (1.9)5.9 (1.0)6.7 (1.1)
Grey matter (%)54.0 (4.9)50.8 (3.0)35.8 (3.4)33.2 (3.1)
White matter (%)42.6 (3.8)44.8 (2.6)61.2 (4.3)62.6 (4.0)
Cerebrospinal fluid (%)3.3 (3.0)4.3 (1.4)2.7 (1.5)4.0 (2.3)
Grey/white matter ratio1.3 (0.2)1.1 (0.1)0.6 (0.1)0.5 (0.1)
  • Values are mean (SD).

  • *Only values considered with CRLB of Gln <20% (subcortical voxel: n = 30 for <25 years and n = 14 for >25 years; frontal voxel: n = 25 for <25 years and n = 21 for >25 years).