Table 3.

Two-way ANOVA of the data shown in Figure 3 (BRL44408) and Figure 4 (naltrindole)

RowFigureExperimentnVariable 1Variable 2InteractionSubject matching
13ACFA9Time (CFA)Sidep < 0.0001p < 0.0001
p < 0.0001p < 0.0001F(7,112) = 18.10F(16,112) = 7.30
F(7,112) = 18.66F(1,16) = 30.49
23BCFA, BRL44408 0.3 nmol6Time (BRL44408)Sidep = 0.75p < 0.0001
p = 0.0064p = 0.93F(5,50) = 0.53F(10,50) = 6.25
F(5,50) = 3.69F(1,10) = 0.007
33CCFA, BRL44408 3 nmol9Time (BRL44408)Sidep = 0.17p < 0.0001
p < 0.0001p = 0.25F(5,80) = 1.60F(16,80) = 3.88
F(5,80) = 19.34F(1,16) = 1.43
43Dsaline8Time (saline)Sidep = 0.92p < 0.0001
p = 0.018p = 0.78F(7,98) = 0.36F(14,98) = 13.1
F(7,98) = 2.56F(1,14) = 0.08
53Esaline (BRL 44408)8Time (BRL44408)Sidep = 0.73p < 0.0001
p = 0.033p = 0.72F(6,84) = 0.60F(14,84) = 12.1
F(6,84) = 2.42F(1,14) = 0.14
64ACFA11Time (CFA)Sidep < 0.0001p < 0.0001
p < 0.0001p = 0.0001F(7,140) = 21.1F(20,140) = 12.8
F(7,140) = 23.15F(1,20) = 22.94
74BCFA, naltrindole i.th.11Time (naltrindole)Sidep = 0.87p = 0.0007
p = 0.0088p = 0.22F(5,100 = 0.36F(20,100 = 2.66
F(5,100) = 3.28F(1,20) = 1.60
84CCFA, naltrindole s.c.8Time (naltrindole)Sidep = 0.14p < 0.0001
p = 0.0033p = 0.97F(5,70) = 1.72F(14,70) = 8.34
F(5,70) = 3.93F(1,14) = 0.0017
94Dsaline8Time (saline)Sidep = 0.30p < 0.0001
p = 0.0001p = 0.71F(7,98) = 1.22F(14,98) = 7.66
F(7,98) = 4.7F(1,14) = 0.15
104Esaline, naltrindole s.c.8Time (naltrindole)Sidep = 0.75p = 0.006
p = 0.49p = 0.022F(5,70) = 0.53F(14,70) = 2.51
F(5,70) = 0.89F(1,14) = 6.6
  • Each panel in Figure 3 or 4 (indicated in the second column) was analyzed independently by two-way ANOVA. In the fourth column, n is the number of animals in the experiment. In the fifth and sixth columns, the variable is identified first: “time” refers to the time after the injection of the compound in parentheses; “side” is ipsilateral versus contralateral paw. Subscript numbers in the F ratio are the degrees of freedom and the residual.