Table 1.

Rate constants for entry and recovery from desensitization based on single-channel recordings and macroscopic recovery rates

Total eventsEntry rate, s−1Recovery rate, s−1Macroscopic recovery rate, s1/recovery rate, s−1
GluN1/GluN2A1,995,9920.07 ± 0.010.48 ± 0.080.92 ± 0.071.08 ± 0.08
(16)(5)
GluN1 (F540L)/812,0880.31 ± 0.09*0.49 ± 0.081.02 ± 0.060.98 ± 0.06
GluN2A(4)(3)
GluN1/25,4752.68 ± 0.81*0.13 ± 0.04*4.02 ± 0.22*0.25 ± 0.01*
GluN2A (F534L)(3)(8)
  • Mean values (±SEM) for the entry and recovery rates derived from the reciprocal of the mean cluster and intercluster durations, respectively, from single-channel recordings (Fig. 3). The number of patches is in parentheses below the total number of events. Macroscopic recovery rates from desensitization and their reciprocal (mean ± SEM) are shown in the right two columns. The number of recordings is shown in parentheses. Significance is shown relative to GluN1/GluN2A (*p < 0.05, Student's t test).