Known CD2AP functions documented in non-neuronal cells that could play a role in axon arbor extension
| Biochemical function | Tissue/cells | Physiological role |
|---|---|---|
| Actin dynamics | Immortalized mouse podocytes (Yaddanapudi et al., 2011; Zhao et al., 2013) | Slit diaphragm integrity |
| Cell motility | ||
| Cell differentiation/spreading | ||
| Lamellipodia formation | ||
| Jurkat T-cells (Dustin et al., 1998) | Antigen recognition at the immune synapse | |
| MDCK cell monolayers (Tang and Brieher, 2013) | Adherens junction integrity | |
| Monolayer resistance to mechanical stress | ||
| Epithelial membrane integrity | ||
| Drosophila melanogaster retinas (Johnson et al., 2008) | Tissue patterning | |
| Signal transduction | Cultured postnatal (P1) sympathetic neurons (Tsui and Pierchala, 2008) | Neuron survival |
| Ligand-dependent ubiquitination of RET51 upon GDNF stimulation | ||
| Direct binding to RET51 | ||
| Immortalized mouse podocytes (Tossidou et al., 2007) | Growth factor signaling | |
| CD2AP enhances PI3K/AKT signaling: FGF, VEGF | ||
| CD2AP enhances ERK1/2 signaling: FGF, VEGF, IGF-1, EGF, PDGF | ||
| NIH3T3 cells (Kobayashi et al., 2004) | VEGF signaling | |
| Interaction with VEGFR1, bridged by c-Cbl | ||
| Receptor internalization | ||
| HEK293T cells (Huber et al., 2003) | Protection from anoikis | |
| Direct binding to p85 | ||
| Positive regulation of AKT pathway | ||
| MDA-MB-231 cells and HeLa cells (Lynch et al., 2003) | Formation of membrane ruffles following EGF stimulation | |
| Interaction with EGFR, bridged by c-Cbl | ||
| Endosome traffic | CHO cells (Cormont et al., 2003) | Endocytosis |
| Immortalized mouse podocytes (Welsch et al., 2005) | Endosome sorting |