Table 2.

Connectivity parameters for each modeled connectiona

PrePostCPre-Post (%)gsynabReference
GPeFSI37.50.1220.23Figure 1; Bevan, et al., 1998
FSIMSN37.5 (DD: 75)0.1520.13Gittis, et al., 2010, 2011; Guzmán, et al., 2003
MSNGPe37.50.0720.08Chuhma, et al., 2011; Shink and Smith, 1995; Miguelez, et al., 2012
GPeGPe250.120.08Bar-Gad, et al., 2003; Bugaysen, et al., 2013; Miguelez, et al., 2012
FSIFSI62.50.0520.19Gittis, et al., 2010
MSNMSN350.0920.1Gertler, et al., 2008; Taverna, et al., 2008; Guzmán, et al., 2003
GPebMSN37.50.00320.12Figure 1
DD: 0.01
  • aModel synaptic parameters, taken directly from experimental data when possible and estimated based on related empirical data otherwise (see Materials and Methods). Pre and Post, Presynaptic and postsynaptic populations, respectively, for the described connection; CPre-Post, connection probability between the populations; gsyn, maximal synaptic conductance (mS/cm2); a and b, constants regulating neurotransmitter release and decay (ms). Values without units are dimensionless.

  • bThe GPe-MSN connection was only included in the model when explicitly noted (e.g., Fig. 4).