Table 2.

Brain regions showing differential activation during aversive learning

RegionVoxels (n)tTalairach coordinates
xyz
Main effect of task condition: CS+> CS−
    dmPFC, anterior cingulate cortex, right inferior frontal gyrus, right middle frontal gyrus, right superior frontal gyrus, right insula, right amygdala, right middle and superior temporal gyri, motor cortex, precuneus58294.2726520
    Left middle and superior temporal gyri, left amygdala, left insula, left nucleus accumbens14904.55−61−12
    Left middle and superior frontal gyri1883.22−252947
    Cerebellum1493.05−34−79−22
Group × task condition: PI > comparisons × CS+>CS−
    Right hippocampus, right parahippocampal cortex413.2423−3410
    Cuneus323.598−7323
Age × task condition: age predicts decreased activation for CS+ > CS−
    Left lateral orbitofrontal cortex1723.06−43−61−25
Group × task condition × age: age predicts decreased activation for comparisons, more activation for PIs for CS+ > CS−
    Cerebellum1723.06−43−61−25
    Midbrain462.962−10−19
    Cerebellum353.4729−52−34
    Precuneus303.8429−5832