Table 1.

Results from SRM proteomics analysis

Protein	Peptide sequence + modification(s)	SRM stats restricted scope			Linear mixed-effects model
Protein	Peptide sequence + modification(s)	Non-adjusted p value	Fold-change estimate	Adjusted p value	Non-adjusted p value	Fold-change estimate	Adjusted p value
Extinction versus control
ADCY9	`GQGTASpPGSpVSDLAQTVK`	0.2413	0.3017	0.3475	0.5004	0.3017	0.7506
AKA12	`ALGSpLGGSpPSLPDQDK`	0.0172	−0.5640	0.0403	0.3275	−0.5640	0.7284
ARHG7	`MSpGFIYQGK`	0.4373	0.0582	0.5524	0.6516	0.0582	0.8530
BAIP2	`SSSpMAAGLER`	0.7626	0.0362	0.8133	0.8628	0.0362	0.9557
BSN	`SPQVLYSpPVSpPLSPHR`	0.0118	0.2460	0.0340	0.1478	0.2460	0.7284
CKD18	`RASpLSDIGFGK`	0.0000	−0.2172	0.0000	0.4012	−0.2172	0.7284
CSKI1	`KVPLPGPGSpPEVK`	0.0173	−0.2256	0.0403	0.1374	−0.2256	0.7284
CTNA1	`SRTpSpVQTpEDDQLIAGQSAR`	0.0144	−0.2016	0.0370	0.1565	−0.2016	0.7284
CTNA1	`SRTSpVQTpEDDQLIAGQSAR`	0.0345	0.1416	0.0653	0.3944	0.1416	0.7284
CTNB1	`RTSMGGTpQQQFVEGVR`	0.2586	−0.0518	0.3581	0.8423	−0.0518	0.9557
CTND2	`ALQSpPEHHIDPIYEDR`	0.9798	−0.0032	0.9798	0.9794	−0.0032	0.9925
CXA1	`M(ox)GQAGSTISpNSpHAQPFDFPDDNQNAK`	0.3219	−0.0462	0.4292	0.8552	−0.0462	0.9557
CXA1	`MGQAGSTISpNSpHAQPFDFPDDNQNAK`	0.0152	−0.3070	0.0377	0.3096	−0.3070	0.7284
CXA1	`VAAGHELQPLAIVDQRPSSpRASpSpR`	0.0000	−0.5198	0.0000	0.0540	−0.5198	0.7284
DGKB	`GAITpPPRSSpPANTCSPEVIHLK`	0.0032	−0.1344	0.0117	0.5449	−0.1344	0.7846
EF1D	`ATAPQTQHVSpPMR`	0.7508	−0.1949	0.8133	0.7508	−0.1949	0.8862
FAK2	`RNSpLPQIPTLNLESR`	0.0000	0.2027	0.0000	0.2270	0.2027	0.7284
FGF12	`EPSpLHEIGEK`	0.2060	−0.1028	0.3027	0.4973	−0.1028	0.7506
GABR1	`HPPTpPPDPSGGLPR`	0.0002	0.1330	0.0011	0.4323	0.1330	0.7284
GABR1	`RHPPTpPPDPSGGLPR`	0.0556	0.1371	0.1002	0.3379	0.1371	0.7284
GABR2	`DPIEDINSpPEHIQR`	0.0035	0.2341	0.0119	0.2114	0.2341	0.7284
GIT1	`HGSpGAESDYENTQSGEPLLGLEGK`	0.0000	−0.2619	0.0002	0.0726	−0.2619	0.7284
GIT1	`NQSDLDDQHDYDSpVASpDEDTDQEPLPSAGATR`	0.1288	0.0910	0.2065	0.3636	0.0910	0.7284
IF3M	`LLYLTpSpAK`	0.5401	0.2342	0.6418	0.5401	0.2342	0.7846
IPP2	`EQESpSpGEEDNDLSPEER`	0.9515	0.0051	0.9787	0.9830	0.0051	0.9925
KCC2A	`ESSESTpNTpTpIEDEDTK`	0.5437	0.0698	0.6418	0.8973	0.0698	0.9762
KCC2A	`ESSpESTNTTIEDEDTK`	0.0000	0.3596	0.0004	0.0737	0.3596	0.7284
KCNQ2	`HGTSpPVGDHGSLVR`	0.1291	−0.2891	0.2065	0.1291	−0.2891	0.7284
KPCB	`HPPVLTpPPDQEVIR`	0.0000	−0.1477	0.0002	0.5564	−0.1477	0.7855
KPCG	`AAPALTpPPDR`	0.5667	−0.2324	0.6535	0.5902	−0.2324	0.8058
KPCG	`TpFCGTPDYIAPEIIAYQPYGK`	0.0008	−0.1151	0.0034	0.4350	−0.1151	0.7284
MARCS	`EAAEAEPAEPGSpPSAETEGASASSTSSPK`	0.0000	0.2408	0.0000	0.1891	0.2408	0.7284
MARCS	`GEAAAERPGEAAVASpSPSK`	0.3813	0.2147	0.4992	0.3813	0.2147	0.7284
MARK2	`DQQNLPFGVTPASpPSGHSQGR`	0.0020	0.1821	0.0075	0.0738	0.1821	0.7284
MINK1	`SDSVLPASHGHLPQAGSpLER`	0.0001	0.1289	0.0005	0.2101	0.1289	0.7284
MK01	`VADPDHDHTGFLTpEYpVATR`	0.0002	0.1278	0.0014	0.3636	0.1278	0.7284
MK10	`TAGTSFMMTpPYpVVTR`	0.0236	−0.4020	0.0499	0.4244	−0.4020	0.7284
NBEA	`EIEDLSQSQSpPESpETDYPVSTDTR`	0.2533	0.0973	0.3576	0.4144	0.0973	0.7284
NBEA	`TPLENVPGNLSpPIKDPDR`	0.0180	−0.1595	0.0406	0.3981	−0.1595	0.7284
NCAM1	`DESpKEPIVEVR`	0.9721	0.0015	0.9798	0.9925	0.0015	0.9925
NCAM2	`ITNHEDGSpPVNEPNETTPLTEPEK`	0.0423	0.1622	0.0781	0.2935	0.1622	0.7284
NCAM2	`ITNHEDGSpPVNEPNETTpPLTEPEK`	0.3886	0.4858	0.4996	0.3886	0.4858	0.7284
NMDE2	`HSQLSDLYpGK`	0.9273	0.0241	0.9676	0.9608	0.0241	0.9925
PAK1	`TVSETPAVPPVSpEDEDDDDDATPPPVIAPRPEHTK`	0.7681	0.0103	0.8133	0.9220	0.0103	0.9762
PEA15	`QPSpEEEIIK`	0.7666	−0.0792	0.8133	0.8489	−0.0792	0.9557
PLCB1	`SEPSSPDHGSSpAIEQDLAALDAEMTQK`	0.0129	−0.1209	0.0344	0.4324	−0.1209	0.7284
PLCB1	`VNLKSpPSpSEEVQGENAGR`	0.1122	0.1155	0.1878	0.3816	0.1155	0.7284
PP1R7	`HGGGIVADLSpQQSpLK`	0.0211	0.1865	0.0460	0.3519	0.1865	0.7284
PPR1B	`IAESHLQTISNLSENQASpEEEDELGELR`	0.0000	−0.3538	0.0001	0.5932	−0.3538	0.8058
PTPRN	`LPEEGGSSpRAEDSSpEGHEEEVLGGHGEK`	0.0263	0.2670	0.0513	0.4188	0.2670	0.7284
RLA1	`KEESpEESpEDDM(ox)GFGLFD`	0.0002	0.2178	0.0013	0.1795	0.2178	0.7284
RLA2	`KEESpEESpDDDM(ox)GFGLFD`	0.0003	0.3184	0.0016	0.1069	0.3184	0.7284
RP3A	`WHQLQNENHVSSpD`	0.4637	−0.2760	0.5757	0.4625	−0.2760	0.7506
SCN2A	`RFSSpPHQSpLLSIR`	0.0005	0.1191	0.0021	0.6348	0.1191	0.8464
SHAN2	`RAPSpPVVSpPTELSK`	0.0002	0.2541	0.0014	0.3608	0.2541	0.7284
SHAN3	`SRSpPSpPSpPLPSPSPGSGPSAGPR`	0.0263	0.2147	0.0513	0.3748	0.2147	0.7284
SRBS2	`SESpMGSpLLCDEGSK`	0.0068	0.4027	0.0204	0.1111	0.4027	0.7284
SRCN1	`DSGSSSVFAESpPGGK`	0.0051	0.1440	0.0161	0.2492	0.1440	0.7284
SRCN1	`KAESpEELEIQKPQVK`	0.6499	0.0178	0.7312	0.9149	0.0178	0.9762
SRCN1	`RFSpNVGLVHTSER`	0.0005	−0.2261	0.0021	0.0394	−0.2261	0.7284
SRCN1	`RGSpDELTVPR`	0.1518	−0.0512	0.2377	0.6823	−0.0512	0.8773
SRCN1	`SSpGATpPVSGPPPPAVSSTPAGQPTAVSR`	0.3208	0.1193	0.4292	0.4850	0.1193	0.7506
STMN1	`DLSpLEEIQK`	0.2030	0.0679	0.3027	0.7102	0.0679	0.8862
STMN1	`ESVPEFPLSpPPK`	0.0251	−0.0784	0.0513	0.7438	−0.0784	0.8862
STMN1	`RASpGQAFELILSpPR`	0.0123	0.2622	0.0340	0.3793	0.2622	0.7284
STX1A	`HSAILASpPNPDEK`	0.0676	−0.1172	0.1187	0.3204	−0.1172	0.7284
STX1A	`TAKDSpDDDDDVTVTVDR`	0.0004	0.1918	0.0020	0.1052	0.1918	0.7284
SYPH	`LHQVYpFDAPSCVK`	0.0847	0.0850	0.1452	0.7301	0.0850	0.8862
SYT1	`DQALKDDDAETGLTpDGEEK`	0.4814	0.1493	0.5875	0.4814	0.1493	0.7506
TNIK	`SEGSpPVLPHEPSK`	0.1999	−0.0503	0.3027	0.3956	−0.0503	0.7284
VIAAT	`GGAPLPPSGSpK`	0.5718	−0.0553	0.6535	0.7363	−0.0553	0.8862
Reactivation versus control
ADCY9	`GQGTASpPGSpVSDLAQTVK`	0.0041	0.5934	0.0084	0.1647	0.5934	0.4146
AKA12	`ALGSpLGGSpPSLPDQDK`	0.7666	−0.0604	0.8119	0.9193	−0.0604	0.9734
ARHG7	`MSpGFIYQGK`	0.0030	0.3177	0.0065	0.1157	0.3177	0.3783
BAIP2	`SSSpMAAGLER`	0.7281	0.0759	0.8119	0.8649	0.0759	0.9730
BSN	`SPQVLYSpPVSpPLSPHR`	0.0063	0.2866	0.0120	0.0908	0.2866	0.3783
CKD18	`RASpLSDIGFGK`	0.1156	−0.0447	0.1734	0.8288	−0.0447	0.9730
CSKI1	`KVPLPGPGSpPEVK`	0.0305	−0.3568	0.0500	0.0260	−0.3568	0.2341
CTNA1	`SRTpSpVQTpEDDQLIAGQSAR`	0.0604	−0.1133	0.0945	0.5393	−0.1133	0.7949
CTNA1	`SRTSpVQTpEDDQLIAGQSAR`	0.0000	0.2878	0.0000	0.0124	0.2878	0.1491
CTNB1	`RTSMGGTpQQQFVEGVR`	0.6712	0.0640	0.7922	0.8436	0.0640	0.9730
CTND2	`ALQSpPEHHIDPIYEDR`	0.7668	0.0369	0.8119	0.7588	0.0369	0.9419
CXA1	`M(ox)GQAGSTISpNSpHAQPFDFPDDNQNAK`	0.0000	0.3038	0.0000	0.1234	0.3038	0.3783
CXA1	`MGQAGSTISpNSpHAQPFDFPDDNQNAK`	0.0000	0.3992	0.0001	0.1918	0.3992	0.4359
CXA1	`VAAGHELQPLAIVDQRPSSpRASpSpR`	0.0000	−0.3599	0.0000	0.0198	−0.3599	0.2037
DGKB	`GAITpPPRSSpPANTCSPEVIHLK`	0.9499	−0.0044	0.9738	0.9901	−0.0044	0.9901
EF1D	`ATAPQTQHVSpPMR`	0.7183	−0.2315	0.8119	0.7183	−0.2315	0.9403
FAK2	`RNSpLPQIPTLNLESR`	0.0000	0.2167	0.0001	0.1670	0.2167	0.4146
FGF12	`EPSpLHEIGEK`	0.0000	−0.8485	0.0000	0.2585	−0.8485	0.5444
GABR1	`HPPTpPPDPSGGLPR`	0.5901	−0.0188	0.7201	0.9144	−0.0188	0.9734
GABR1	`RHPPTpPPDPSGGLPR`	0.4862	−0.0397	0.6251	0.8359	−0.0397	0.9730
GABR2	`DPIEDINSpPEHIQR`	0.0054	−0.2011	0.0105	0.3330	−0.2011	0.5994
GIT1	`HGSpGAESDYENTQSGEPLLGLEGK`	0.3029	−0.0707	0.4194	0.5410	−0.0707	0.7949
GIT1	`NQSDLDDQHDYDSpVASpDEDTDQEPLPSAGATR`	0.0002	0.2143	0.0005	0.0370	0.2143	0.2661
IF3M	`LLYLTpSpAK`	0.7412	0.1111	0.8119	0.7412	0.1111	0.9419
IPP2	`EQESpSpGEEDNDLSPEER`	0.0052	0.3180	0.0104	0.2948	0.3180	0.5736
KCC2A	`ESSESTpNTpTpIEDEDTK`	0.0003	0.4759	0.0008	0.0322	0.4759	0.2578
KCC2A	`ESSpESTNTTIEDEDTK`	0.0000	−0.6186	0.0001	0.4973	−0.6186	0.7949
KCNQ2	`HGTSpPVGDHGSLVR`	0.1937	−1.4748	0.2847	0.1937	−1.4748	0.4359
KPCB	`HPPVLTpPPDQEVIR`	0.0000	−0.1782	0.0000	0.6023	−0.1782	0.8339
KPCG	`AAPALTpPPDR`	0.3605	−0.3204	0.4806	0.3961	−0.3204	0.6633
KPCG	`TpFCGTPDYIAPEIIAYQPYGK`	0.0000	−0.2607	0.0000	0.1253	−0.2607	0.3783
MARCS	`EAAEAEPAEPGSpPSAETEGASASSTSSPK`	0.0000	0.3923	0.0000	0.0730	0.3923	0.3726
MARCS	`GEAAAERPGEAAVASpSPSK`	0.2646	−1.9668	0.3736	0.2646	−1.9668	0.5444
MARK2	`DQQNLPFGVTPASpPSGHSQGR`	0.0000	0.2598	0.0001	0.0023	0.2598	0.0559
MINK1	`SDSVLPASHGHLPQAGSpLER`	0.0085	0.1011	0.0153	0.3707	0.1011	0.6509
MK01	`VADPDHDHTGFLTpEYpVATR`	0.0004	0.1374	0.0008	0.3844	0.1374	0.6590
MK10	`TAGTSFMMTpPYpVVTR`	0.0002	0.7296	0.0004	0.1492	0.7296	0.4132
NBEA	`EIEDLSQSQSpPESpETDYPVSTDTR`	0.0088	0.2889	0.0155	0.0659	0.2889	0.3648
NBEA	`TPLENVPGNLSpPIKDPDR`	0.0003	−0.2541	0.0006	0.1069	−0.2541	0.3783
NCAM1	`DESpKEPIVEVR`	0.4820	−0.0317	0.6251	0.8555	−0.0317	0.9730
NCAM2	`ITNHEDGSpPVNEPNETTPLTEPEK`	0.9769	−0.0021	0.9769	0.9894	−0.0021	0.9901
NCAM2	`ITNHEDGSpPVNEPNETTpPLTEPEK`	0.5354	−0.3821	0.6763	0.5354	−0.3821	0.7949
NMDE2	`HSQLSDLYpGK`	0.9603	0.0113	0.9738	0.9690	0.0113	0.9901
PAK1	`TVSETPAVPPVSpEDEDDDDDATPPPVIAPRPEHTK`	0.2036	−0.0521	0.2932	0.6999	−0.0521	0.9383
PEA15	`QPSpEEEIIK`	0.7288	0.0539	0.8119	0.8991	0.0539	0.9734
PLCB1	`SEPSSPDHGSSpAIEQDLAALDAEMTQK`	0.0348	0.1013	0.0558	0.7037	0.1013	0.9383
PLCB1	`VNLKSpPSpSEEVQGENAGR`	0.5520	−0.1562	0.6853	0.5302	−0.1562	0.7949
PP1R7	`HGGGIVADLSpQQSpLK`	0.0001	0.4104	0.0002	0.0546	0.4104	0.3275
PPR1B	`IAESHLQTISNLSENQASpEEEDELGELR`	0.0000	−0.4040	0.0000	0.5816	−0.4040	0.8211
PTPRN	`LPEEGGSSpRAEDSSpEGHEEEVLGGHGEK`	0.0001	0.4983	0.0003	0.1004	0.4983	0.3783
RLA1	`KEESpEESpEDDM(ox)GFGLFD`	0.0000	0.3790	0.0000	0.0048	0.3790	0.0868
RLA2	`KEESpEESpDDDM(ox)GFGLFD`	0.0001	0.4373	0.0003	0.0009	0.4373	0.0559
RP3A	`WHQLQNENHVSSpD`	0.0067	−0.4470	0.0124	0.5687	−0.4470	0.8189
SCN2A	`RFSSpPHQSpLLSIR`	0.0000	0.4239	0.0000	0.0446	0.4239	0.2922
SHAN2	`RAPSpPVVSpPTELSK`	0.0000	0.3424	0.0000	0.2148	0.3424	0.4686
SHAN3	`SRSpPSpPSpPLPSPSPGSGPSAGPR`	0.0009	0.5152	0.0019	0.1261	0.5152	0.3783
SRBS2	`SESpMGSpLLCDEGSK`	0.0002	0.6422	0.0005	0.0801	0.6422	0.3726
SRCN1	`DSGSSSVFAESpPGGK`	0.0000	0.2076	0.0001	0.1560	0.2076	0.4146
SRCN1	`KAESpEELEIQKPQVK`	0.0146	−0.1133	0.0250	0.4970	−0.1133	0.7949
SRCN1	`RFSpNVGLVHTSER`	0.0000	−0.3600	0.0001	0.0083	−0.3600	0.1191
SRCN1	`RGSpDELTVPR`	0.0001	−0.2053	0.0004	0.1774	−0.2053	0.4259
SRCN1	`SSpGATpPVSGPPPPAVSSTPAGQPTAVSR`	0.9596	0.0141	0.9738	0.9630	0.0141	0.9901
STMN1	`DLSpLEEIQK`	0.6268	0.0313	0.7522	0.8983	0.0313	0.9734
STMN1	`ESVPEFPLSpPPK`	0.3329	−0.0552	0.4523	0.7488	−0.0552	0.9419
STMN1	`RASpGQAFELILSpPR`	0.0000	0.5433	0.0001	0.1049	0.5433	0.3783
STX1A	`HSAILASpPNPDEK`	0.0193	−0.1344	0.0323	0.3284	−0.1344	0.5994
STX1A	`TAKDSpDDDDDVTVTVDR`	0.7533	−0.0147	0.8119	0.8233	−0.0147	0.9730
SYPH	`LHQVYpFDAPSCVK`	0.0037	−0.4914	0.0079	0.2792	−0.4914	0.5583
SYT1	`DQALKDDDAETGLTpDGEEK`	0.0828	−0.2498	0.1269	0.0828	−0.2498	0.3726
TNIK	`SEGSpPVLPHEPSK`	0.0000	−0.3677	0.0001	0.0019	−0.3677	0.0559
VIAAT	`GGAPLPPSGSpK`	0.0002	−0.4927	0.0005	0.3042	−0.4927	0.5763