Effects of CNO on anogenital investigationa
| Group | Day 1 | Day 5 |
|---|---|---|
| Numbers | ||
| Saline | 7.33 ± 1.26 | 3.17 ± 1.85b |
| CNO | 6.00 ± 0.55 | 4.22 ± 1.18b |
| Latencies | ||
| Saline | 14.33 ± 3.70 s | 17.25 ± 8.72 s |
| CNO | 23.50 ± 1.26 s | 12.71 ± 3.88 s |
| % Males | ||
| Saline | 100.00 | 50.00 |
| CNO | 100.00 | 77.78 |
↵aCNO did not affect anogenital investigations during acquisition of sexual experience. Quantitative analysis of numbers of anogenital investigations, latencies (seconds) to first anogenital investigation, and percentages of males that display anogenital investigations, during the first 2 min of day 1 and day 5 of 5 consecutive days of sexual behavior in saline-treated (n = 6) and CNO-treated (n = 9) TH::Cre transgenic rats expressing Gi DREADD in VTA TH cells. Data represent mean ± SEM.
↵bSignificant difference compared to day 1. No significant differences between saline and CNO groups were detected.