Table 1.

Changes in VGLUT1 immunoreactivity in male APOE3 and APOE4 mice

30 dpl70 dpl170 dpl
Sh.e3Les.e3pSh.e4Les.e4pSh.e3Les.e3pSh.e4Les.e4pSh.e3Les.e3pSh.e4Les.e4p
DG oML1 ± 0.060.85 ± 0.060.101 ± 0.070.72 ± 0.030.011 ± 0.081.03 ± 0.070.681 ± 0.060.89 ± 0.040.191 ± 0.030.81 ± 0.050.021 ± 0.080.87 ± 0.060.11
DG mML1 ± 0.010.63 ± 0.030.011 ± 0.070.57 ± 0.030.011 ± 0.060.85 ± 0.020.091 ± 0.050.70 ± 0.020.011 ± 0.020.95 ± 0.050.571 ± 0.090.91 ± 0.060.24
DG iML1 ± 0.010.86 ± 0.040.111 ± 0.050.85 ± 0.030.051 ± 0.081.08 ± 0.020.311 ± 0.050.92 ± 0.030.731 ± 0.041.01 ± 0.050.861 ± 0.090.98 ± 0.050.86
DG HIL1 ± 0.010.85 ± 0.040.111 ± 0.040.84 ± 0.020.031 ± 0.071.02 ± 0.030.751 ± 0.020.94 ± 0.040.521 ± 0.060.96 ± 0.050.631 ± 0.071.01 ± 0.050.96
CA3 oLM1 ± 0.080.89 ± 0.050.231 ± 0.070.81 ± 0.040.011 ± 0.081.08 ± 0.060.311 ± 0.040.90 ± 0.060.251 ± 0.030.83 ± 0.040.041 ± 0.080.86 ± 0.050.09
CA3 iLM1 ± 0.080.78 ± 0.040.021 ± 0.060.64 ± 0.030.011 ± 0.040.96 ± 0.050.721 ± 0.050.82 ± 0.050.041 ± 0.040.87 ± 0.050.121 ± 0.100.85 ± 0.060.06
CA3 RAD1 ± 0.020.86 ± 0.050.141 ± 0.050.83 ± 0.040.031 ± 0.031.08 ± 0.050.311 ± 0.010.99 ± 0.030.921 ± 0.050.98 ± 0.060.811 ± 0.100.93 ± 0.040.44
CA3 LUC1 ± 0.030.91 ± 0.050.351 ± 0.040.86 ± 0.040.071 ± 0.041.03 ± 0.040.701 ± 0.031.01 ± 0.040.831 ± 0.051.01 ± 0.060.881 ± 0.110.93 ± 0.040.40
CA3 OR1 ± 0.050.92 ± 0.060.411 ± 0.020.84 ± 0.040.041 ± 0.041.03 ± 0.040.721 ± 0.041.03 ± 0.060.711 ± 0.060.95 ± 0.040.611 ± 0.100.94 ± 0.040.49
CA2 oLM1 ± 0.090.95 ± 0.060.631 ± 0.080.84 ± 0.040.051 ± 0.061.09 ± 0.070.291 ± 0.030.95 ± 0.070.611 ± 0.020.82 ± 0.050.061 ± 0.080.91 ± 0.050.32
CA2 iLM1 ± 0.060.70 ± 0.030.011 ± 0.070.61 ± 0.030.011 ± 0.050.95 ± 0.050.641 ± 0.040.79 ± 0.060.021 ± 0.030.89 ± 0.040.231 ± 0.090.87 ± 0.060.15
CA2 RAD1 ± 0.020.97 ± 0.060.111 ± 0.050.84 ± 0.040.051 ± 0.061.09 ± 0.050.301 ± 0.030.96 ± 0.050.731 ± 0.041.01 ± 0.060.831 ± 0.080.97 ± 0.040.80
CA2 OR1 ± 0.020.91 ± 0.080.401 ± 0.030.83 ± 0.530.041 ± 0.071.02 ± 0.060.781 ± 0.031.01 ± 0.040.871 ± 0.051.06 ± 0.070.481 ± 0.091.01 ± 0.040.98
CA1 LM1 ± 0.040.80 ± 0.040.011 ± 0.070.68 ± 0.040.011 ± 0.061.03 ± 0.030.621 ± 0.080.84 ± 0.030.041 ± 0.040.91 ± 0.050.251 ± 0.070.87 ± 0.040.08
CA1 RAD1 ± 0.050.97 ± 0.060.751 ± 0.030.79 ± 0.030.011 ± 0.041.11 ± 0.030.151 ± 0.010.98 ± 0.040.831 ± 0.020.96 ± 0.040.641 ± 0.070.96 ± 0.040.66
CA1 OR1 ± 0.060.94 ± 0.060.511 ± 0.030.83 ± 0.040.021 ± 0.071.05 ± 0.030.471 ± 0.021.01 ± 0.050.841 ± 0.030.92 ± 0.040.341 ± 0.070.98 ± 0.050.87

  • VGLUT1 immunoreactivity levels are provided for all male groups (expressed as a ratio of respective sham group). Significant differences (p < 0.05, Fisher's LSD) are highlighted in red. Data are presented as mean ± SEM.