Table 1.

Effects of Trem2 deficiency on AD-related pathologies

Mouse modelAge, moBrain regionApproximate stage of amyloid depositionChanges in amyloid pathologyAccumulation of myeloid cells around plaquesInflammatory gene transcript levelsReference
5XFAD;Trem2−/−4CortexEarly–middleN/AWang et al., 2016
HippocampusMiddleN/A
5XFAD;Trem2−/−8.5CortexMiddle–lateWang et al., 2015
HippocampusLate
APPPS1;Trem2−/−2CortexEarlyCurrent Study
APPPS1;Trem2−/−;Cx3cr1GFP/+3UnknownN/AN/AN/AWang et al., 2015
APPPS1;Trem2−/−4–4.5CortexMiddleJay et al., 2015
HippocampusEarly
APPPS1;Trem2−/−8CortexLateCurrent study
HippocampusMiddle–late↓ (data not shown)↓ (data not shown)Current study