Table 1.

Loss of YFP+/TH+ cells in the central mDA region of Neurod6Cre/Cre;R26RYFP/YFP mutants per brain hemispherea

E18.5P3P14Adult
n3333
Neurod6 controls (mean ± SEM)200 ± 3232 ± 5207 ± 1270 ± 16
Neurod6 mutants (mean ± SEM)211 ± 27167 ± 10143 ± 14185 ± 26
% of YFP+/TH+ mDA cells lost in mutants relative to controlsNA283132
Average no. of cells lost in mutants (mean ± SEM)NA65 ± 1465 ± 1485 ± 15
SignificanceNS*****
p value0.690.0040.0010.05
  • aRaw data of the numbers of mDA neurons counted per brain hemisphere in the central mDA region and the results from statistical analysis, comparing cell counts between Neurod6 mutant and control brains at each stage using the unpaired Student's t test. n, Number of brain samples analyzed; NA, not applicable; NS, not significant.

  • *p < 0.05 (Student's t test);

  • **p < 0.005 (Student's t test).