Results from the protein discovery study using LC-MSE in frontal cortex tissue of HOM (n = 14) and HET (n = 17) Disc1-mutant mice versus WT mice (n = 15)
| Protein | WT-HOM mice | WT-HET mice | ||
|---|---|---|---|---|
| Ratio Disc1/WT | P | Ratio Disc1/WT | p | |
| 1433B | 1.03 | 0.4259 | 1.08 | 0.0258 |
| 1433G | 0.97 | 0.212 | 0.94 | 0.0099 |
| AATM | 0.95 | 0.1705 | 0.93 | 0.0501 |
| AP2B1 | 1 | 0.9585 | 0.93 | 0.0408 |
| ARF4 | 1.14 | 0.3023 | 1.34 | 0.0263 |
| BPHL | 0.94 | 0.4688 | 0.81 | 0.0176 |
| DPYL2 | 0.99 | 0.6338 | 0.96 | 0.0469 |
| EAA2 | 0.95 | 0.2693 | 0.9 | 0.022 |
| EF1A1 | 0.93 | 0.1041 | 0.89 | 0.021 |
| MATN4 | 0.94 | 0.493 | 0.8 | 0.0158 |
| PDZD9 | 0.96 | 0.6226 | 0.83 | 0.0346 |
| PMF1 | 0.91 | 0.3581 | 0.81 | 0.0336 |
| Septin-7 (39326) | 0.98 | 0.5595 | 0.92 | 0.0409 |
| UB2L3 | 0.99 | 0.9374 | 0.78 | 0.0358 |
| CALM | 1.16 | 0.0315 | 1.11 | 0.1139 |
| DPYL1 | 1.07 | 0.0234 | 1.05 | 0.0788 |
| HS90A | 1.09 | 0.0309 | 1.08 | 0.0409 |
The table includes Uniprot ID, ratios (calculated based on average), and p values. Note that the adjusted p value (q value) for all listed proteins is not significant (q = 0.8620). In bold are the proteins with a p value <0.05. HS90A, Heat shock protein HSP 90-α; CALM, calmodulin; UB2L3, ubiquitin-conjugating enzyme E2 L3; PMF1, polyamine-modulated factor 1; PDZD9, PDZ domain-containing protein 9; MATN4, matrilin-4; EF1A1, elongation factor 1-α 1; EAA2, excitatory amino acid transporter 2; BPHL, valacyclovir hydrolase; ARF4, ADP-ribosylation factor 4; AP2B1, AP-2 complex subunit β; AATM, aspartate aminotransferase; 1433G, 14-3-3 protein γ; 1433B, 14-3-3 protein β/α.