Demographics of N = 54 participants who underwent [11C]raclopride DRD2 baseline and intravenous MP scans; separated for AKT1 genotype
| HH n = 19 (6 female; 31.6%) | HL n = 27 (7 female; 25.9%) | LL n = 8 (0 female; 0%) | χ2 = 3.17 | p = 0.21 | ||||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | F2,53 | P value | |
| Demographics | ||||||||
| Age (years) | 34.8 | 7.9 | 35.3 | 8.3 | 38.8 | 9.8 | 0.69 | 0.51 |
| Education (years) | 14.9 | 2.8 | 14.4 | 2.1 | 14.1 | 1.7 | 0.42 | 0.66 |
| Body mass index | 25.3 | 2.3 | 26.4 | 2.6 | 24.4 | 3.4 | 2.13 | 0.13 |
| Beck depression inventory | 2.6 | 3.6 | 4.4 | 7.1 | 3.1 | 4.2 | 0.55 | 0.58 |
| n | % | n | % | n | % | X2 | P value | |
| Ethnicity | ||||||||
| African American | 11 | 58 | 11 | 41 | 2 | 25 | 17.36 | 0.008 |
| Caucasian | 1 | 5 | 9 | 33 | 6 | 75 | ||
| Hispanic | 4 | 21 | 1 | 4 | 0 | 0 | ||
| More than one | 3 | 16 | 6 | 22 | 0 | 0 | ||
| Mean | SD | Mean | SD | Mean | SD | F(2,53) | P value* | |
|---|---|---|---|---|---|---|---|---|
| DA release (BPND placebo–MP) | ||||||||
| Caudate | 0.55 | 0.56 | 0.36 | 0.33 | 0.22 | 0.16 | 2.14 | 0.13 |
| Putamen | 0.93 | 0.66 | 0.74 | 0.42 | 0.49 | 0.45 | 1.39 | 0.26 |
| VS | 0.76 | 0.59 | 0.35 | 0.48 | 0.03 | 0.72 | 5.25 | 0.009 |
↵*Multivariate test corrected for age, gender, and ethnicity.