Table 1.

Membrane properties of WT, D/+, and D/D mEC layer II stellate neurons

RMP, mVRi, MΩThreshold, mVAmplitude, mVAPD50, msAPD90, msUpstroke velocity, mV/msDownstroke velocity, mV/msn
1st AP
    WT−65.8 ± 1.1111.8 ± 10.9−40.4 ± 1.442.1 ± 1.70.8 ± 0.12.5 ± 0.1268.0 ± 9.1−77.5 ± 3.520
    D/+−66.1 ± 1.2112.6 ± 11.2−41.3 ± 4.247.3 ± 1.4a2.5 ± 0.2a7.1 ± 0.7a190.2 ± 19.4a−34.6 ± 2.2a20
    D/D−65.7 ± 2.1110.7 ± 13.2−41.6 ± 1.246.4 ± 1.3a3.3 ± 0.2a,b9.6 ± 1.2a168.6 ± 5.8a,b−21.4 ± 2.7a,b21
2nd AP
    WT−37.4 ± 0.940.9 ± 0.91.4 ± 0.12.9 ± 0.1218.0 ± 10.2c−48.6 ± 2.5c20
    D/+−36.5 ± 1.1c33.6 ± 2.9a,c4.8 ± 0.8a,c8.7 ± 0.7a,c100.2 ± 22.0a,c−19.2 ± 2.9a,c20
    D/D−32.8 ± 1.8a,c25.4 ± 0.9a,b,c7.7 ± 0.5a,b,c14.4 ± 1.2a,b,c55.6 ± 7.1a,b,c−12.8 ± 2.6a,b,c21
3rd AP
    WT−37.9 ± 0.941.4 ± 2.71.3 ± 0.82.9 ± 0.2229.7 ± 11.8c−59.3 ± 1.2c20
    D/+−35.9 ± 1.7c38.3 ± 1.8c,d5.2 ± 0.6a,c9.7 ± 1.7a,c98.5 ± 17.9a,c−19.0 ± 1.9a,c20
    D/D−31.1 ± 1.1a,b,c32.9 ± 1.1a,b,c,d8.2 ± 1.7a,b,c14.1 ± 1.8a,b,c53.7 ± 7.1a,b,c−13.0 ± 3.5a,b,c21
  • Values represent mean ± SEM. n = number of cells.

  • ap < 0.05 versus WT neurons.

  • bp < 0.05 D/+ versus D/D.

  • cp < 0.05 1st AP versus 2nd and 3rd APs within the same genotype.

  • dp < 0.05 2nd versus 3rd AP within the same genotype.