Table 1.

Experimental details

MonkeyWeight, kgInj. mass, μg/kgBPNDDrugDrug dose, μg/kgTime of administration, minInduction anesthetics
M110.60.702.15BSLType 1
M37.40.412.04BSLType 1
M211.40.132.02AZ0.8855.2Type 1
M110.60.121.91AZ0.9465.5Type 1
M110.60.272.09AZ1.8952.3Type 1
M110.60.122.07AZ2.8655.0Type 1
M37.40.251.94AZ4.0562.4Type 1
M212.00.561.74AZ4.1760.0Type 2
M310.30.341.90AZ4.8559.9Type 2
M213.80.150.88AZ5.0060.0Type 2
M213.80.140.61AZ36.2040.0Type 2
AZ5.0060.0
M310.30.371.67Sumatriptan19.459.6Type 2
M212.00.301.70GR12793520060.0Type 2
M312.20.421.12GR12793520062.8Type 2
M312.20.31n.a.GR127935500−14.0Type 2
AZ5.0060.1
  • BPND represent the baseline nondisplaceable binding potential before a challenge. BSL indicates a baseline experiment, where no challenge was given. Time of administration of the drug is relative to the injection (inj.) of the radioligand. Induction of anesthesia was performed in two ways: Type 1: diazepam (0.4 mg/kg) + ketamine (20 mg/kg); Type 2: ketamine (10 mg/kg) + xylazine (0.5 mg/kg) following reversal of xylazine with yohimbine (0.11 mg/kg).