Table 1.

Human PheWAS identifies neuropsychiatric disorders associated with the integrin β3 coding polymorphism Leu33Pro (rs5918)

Psychiatric disorder	Adult females				Adult males
Psychiatric disorder	Case patients	Control subjects	OR	p value	Case patients	Control subjects	OR	p value
ADHD	54	13,561	1.24	0.3745	46	11,371	2.09	0.0014
Pervasive developmental disorders (ASDs)	66	13,561	1.21	0.4067	61	11,371	1.91	0.0018
Schizophrenia	47	8478	0.97	0.9260	29	8404	0.39	0.0683
Suicidal ideation or attempt	48	8478	1.18	0.5325	55	8404	0.58	0.0872
Antisocial/borderline personality disorder	39	8478	0.92	0.7924	14	8404	0.19	0.1061
Suicidal ideation	26	8478	1.53	0.1970	30	8404	0.48	0.1108
Major depressive disorder	499	8478	1.08	0.3699	273	8404	1.18	0.1328
Psychogenic and somatoform disorders	92	8478	0.84	0.4269	21	8404	0.41	0.1331
Agoraphobia, social phobia, and panic disorder	121	8478	1.17	0.3423	54	8404	0.66	0.1717
Transient alteration of awareness	48	11202	0.81	0.4855	31	9205	0.58	0.1989
Obsessive-compulsive disorders	30	8478	0.90	0.7733	17	8404	1.58	0.2542
Personality disorders	66	8478	0.86	0.5331	32	8404	0.64	0.2689
Generalized anxiety disorder	189	8478	0.84	0.2440	101	8404	1.22	0.2700
Other specified nonpsychotic and/or transient mental disorders	612	11,202	1.04	0.6052	630	9205	0.92	0.3314
Posttraumatic stress disorder	134	8478	1.03	0.8740	55	8404	1.24	0.3703
Eating disorder	35	8478	1.50	0.1554	6	8404	1.72	0.4136
Anxiety, phobic and dissociative disorders	1968	8478	1.00	0.9188	950	8404	0.95	0.4144
Anxiety disorder	1559	8478	0.95	0.3228	731	8404	0.95	0.4749
Aphasia/speech disturbance	242	11,202	1.18	0.1526	237	9205	0.91	0.4904
Bipolar	226	8478	0.74	0.0350	152	8404	1.10	0.5250
Dysthymic disorder	419	8478	1.10	0.3009	177	8404	0.93	0.6514
Mental retardation	48	13,561	0.87	0.6415	48	11,371	0.92	0.7791
Depression	2370	8478	1.04	0.3252	1276	8404	0.99	0.8735
Mood disorders	2565	8478	1.04	0.4239	1435	8404	1.00	0.9278
Conduct disorders	36	13,561	0.92	0.8067	42	11,371	0.99	0.9675

Odds ratios (ORs) are reported as increased risk for the rare allele Pro33. p values are presented as raw, uncorrected values. Italics is used to indicate disorders with statistically significant associations.