Table 4.

Bonferroni post hoc comparison for two-way ANOVA

Figure	Comparison	p	Figure	Comparison	p	Figure	Comparison	p
1B	At 3 h: Veh versus 6-ODHA	0.043	5F	At 3 h: WT versus DRD5KO	0.0021		WT: D9 versus 24 h	0.037
	At 24 h: Veh versus 6-ODHA	0.025		At 24 h: WT versus DRD5KO	0.0234		DRD5KO: D9 versus 3 h	0.72
	BDNF/Veh: D7 versus 3 h	0.026		WT: BL versus 3 h	<0.0001		DRD5KO: D9 versus 24 h	0.042
	BDNF/6-ODHA: D7 versus 3 h	>0.99		WT: BL versus 24 h	<0.0001	6G	At 3 h: WT versus DRD5KO	0.009
	BDNF/Veh: D7 versus 24 h	0.011		DRD5KO: BL versus 3 h	0.0032		At 24 h: WT versus DRD5KO	0.14
	BDNF/6-ODHA: D7 versus 24 h	>0.99		DRD5KO: BL versus 24 h	0.002		WT: D7 versus 3 h	<0.0001
1C	At 3 h: Veh versus 6-ODHA	0.047	5H	At 3 h: WT versus DRD5KO	>0.99		WT: D7 versus 24 h	<0.0001
	At 24 h: Veh versus 6-ODHA	0.14		At 24 h: WT versus DRD5KO	>0.99		DRD5KO: D7 versus 3 h	0.1206
	BDNF/Veh: D7 versus 3 h	0.0015		WT: BL versus 3 h	0.0003		DRD5KO: D7 versus 24 h	0.079
	BDNF/6-ODHA: D7 versus 3 h	0.68		WT: BL versus 24 h	0.0002	6H	At 3 h: WT versus DRD5KO	0.106
	VDNF/Veh: D7 versus 24 h	0.021		DRD5KO: BL versus 3 h	<0.0001		At 24 h: WT versus DRD5KO	0.011
	VDNF/6-ODHA: D7 versus 24 h	0.93		DRD5KO: BL versus 24 h	<0.0001		WT: D7 versus 3 h	0.0033
1D	At 3 h: BDNF/Veh versus BDNF/6-ODHA	0.38	5I	At BL: WT versus DRD5KO	0.033		WT: D7 versus 24 h	0.0002
	At 24 h: BDNF/Veh versus BDNF/6-ODHA	0.029		At 48 h: WT versus DRD5KO	0.020		DRD5KO: D7 versus 3 h	0.0212
	Veh/6-ODHA: D7 versus 3 h	>0.99		WT: BL versus 3 h	0.047		DRD5KO: D7 versus 24 h	0.013
	Veh/6-ODHA: D7 versus 24 h	>0.99		WT: BL versus 24 h	0.021	6I	WT: BL versus 3,24,48,72 h	<0.0001
	BDNF/Veh: D7 versus 3 h	0.012		WT: BL versus 48 h	0.83		DRD5KO: BL versus 3,24,48,72 h	<0.0001
	BDNF/Veh: D7 versus 24 h	>0.0048		DRD5KO: BL versus 3 h	0.0016	6J	At 3 h: WT versus DRD5KO	0.037
	BDNF/6-ODHA: D7 versus 3 h	0.58		DRD5KO: BL versus 24 h	0.92		At 24 h: WT versus DRD5KO	0.063
	BDNF/6-ODHA: D7 versus 24 h	>0.99		DRD5KO: BL versus 48 h	>0.99		WT: D7 versus 3, 24 h	<0.0001
1E	At 3 h: Veh versus BDNF	<0.0001	5J	At 3 h: WT versus DRD5KO	0.43		DRD5KO: D7 versus 3, 24 h	<0.0001
	At 24 h: Veh/SKF versus BDNF/SKF	<0.001		At 24 h: WT versus DRD5KO	0.98	9C	At 3 h: Veh versus gabazine	0.0012
	At 48 h: Veh/SKF versus BDNF/SKF	<0.001		WT: BL versus 3 h	0.003		At 24 h: Veh versus gabazine	0.24
1F	BDNF: BL versus 3, 24, and 48 h	<0.0001		WT: BL versus 24 h	0.10		Veh: BL versus 3 h	>0.99
	Females 3 h: Veh versus BDNF	0.048		DRD5KO: BL versus 3 h	0.0026		Veh: BL versus 24 h	0.25
	Males 3 h: Veh versus BDNF	0.0080		DRD5KO: BL versus 24 h	0.035		gabazine: BL versus 3 h	<0.0001
	Females 24 h: Veh versus BDNF	0.16	5K	At 48 h: WT versus DRD5KO	0.092		gabazine: BL versus 24 h	0.22
	Males 24 h: Veh versus BDNF	0.0283		WT: BL versus 3 h	0.013	9D	At 3 h: SKF/Veh versus SKF/gabazine	0.001
	Females BDNF/SKF: BL versus 3 h	0.0294		WT: BL versus 24 h	0.0018		At 24 h: SKF/Veh versus SKF/gabazine	>0.99
	Males BDNF/SKF: BL versus 3 h	0.0043		WT: BL versus 48 h	0.65		SKF/Veh: D7 versus 3 h	<0.0001
	Females BDNF/SKF: BL versus 24 h	0.20		DRD5KO: BL versus 3 h	0.042		SKF/Veh: D7 versus 24 h	0.0265
	Males BDNF/SKF: BL versus 24 h	0.0039		DRD5KO: BL versus 24 h	0.020		SKF/gabazine: D7 versus 3 h	>0.99
1G	At 3 h: Veh versus SCH23390	0.0136		DRD5KO: BL versus 48 h	>0.99		SKF/gabazine: D7 versus 24 h	0.46
	At 6 h: Veh versus SCH23390	0.12	5L	At 3 h: WT versus DRD5KO	>0.99
	Veh/SCH23390: BL versus 3 h	<0.0001		At 24 h: WT versus DRD5KO	0.0125
	Veh/SCH23390: BL versus 6 h	<0.0001		WT: BL versus 3 h	0.039
	BDNF/SCH23390: BL versus 3 h	0.63		WT: BL versus 24 h	>0.99
1H	BDNF/SCH23390: BL versus 6 h	0.0501		DRD5KO: BL versus 3 h	0.0005
	At 1 h: Veh versus SCH23390 3.3 μg	0.0120		DRD5KO: BL versus 24 h	0.0019
	At 3 h: Veh versus SCH23390 3.3 μg	0.027	5O	At 3 h: WT versus DRD5KO	>0.99
	At 1 h: Veh versus SCH23390 5 μg	0.045		At 3 h: WT versus DRD5KO	0.78
	At 3 h: Veh versus SCH23390 5 μg	0.0325	6A	At 3 h: WT versus DRD5KO	0.025
3A	At 20 min: WT versus DRD5KO	0.045		At 48 h: WT versus DRD5KO	0.048
	At 25 min: WT versus DRD5KO	0.013		At 72 h: WT versus DRD5KO	0.0007
	At 30 min: WT versus DRD5KO	0.006		WT: BL versus 3,24,48,72 h	<0.05
3E	At 30 min: WT versus DRD5KO	0.091		DRD5KO: BL versus 3 h	>0.99
	At 35 min: WT versus DRD5KO	0.85		DRD5KO: BL versus 24 h	0.34
5B	At 3 h: WT versus DRD5KO	0.045		DRD5KO: BL versus 48 h	0.99
	At 24 h: WT versus DRD5KO	0.058	6B	At 3 h: WT versus DRD5KO	0.65
	WT: BL versus 3 h	<0.0001		At 24 h: WT versus DRD5KO	0.035
	WT: BL versus 24 h	<0.0001		WT: D9 versus 3 h	0.028
	DRD5KO: BL versus 3 h	0.002		WT: D9 versus 24 h	0.047
	DRD5KO: BL versus 24 h	0.005		DRD5KO: D9 versus 3 h	>0.99
5C	At 3 h: WT versus DRD5KO	0.032		DRD5KO: D9 versus 24 h	>0.99
	At 24 h: WT versus DRD5KO	0.42	6C	At 3,24,48 h: WT versus DRD5KO	>0.99
	WT: BL versus 3 h	0.0021		WT: BL versus 3,24,48,72 h	<0.0001
	WT: BL versus 24 h	0.038		DRD5KO: BL versus 3,24,48,72 h	<0.0001
	DRD5KO: BL versus 3 h	>0.99	6D	At 3 & 24 h: WT versus DRD5KO	>0.99
	DRD5KO: BL versus 24 h	>0.099		WT: D9 versus 3 h	<0.001
5D	At 3 h: WT versus DRD5KO	0.28		DRD5KO: D9 versus 3 h	<0.001
	At 24 h: WT versus DRD5KO	0.0132	6E	At 3 h: WT versus DRD5KO	0.039
	WT: BL versus 3 h	<0.0001		At 24 h: WT versus DRD5KO	0.279
	WT: BL versus 24 h	0.0002		At 48 h: WT versus DRD5KO	>0.99
	DRD5KO: BL versus 3 h	0.074		WT: BL versus 3 h	0.020
	DRD5KO: BL versus 24 h	0.99		WT: BL versus 24 h	0.14
5E	At 3 h: WT versus DRD5KO	0.4		WT: BL versus 48 h	0.996
	At 24 h: WT versus DRD5KO	0.0093		DRD5KO: BL versus 3 h	0.96
	At 48 h: WT versus DRD5KO	0.032		DRD5KO: BL versus 24 h	0.96
	WT: BL versus 3, 24, 48 h	<0.0001		DRD5KO: BL versus 48 h	0.989
	DRD5KO: BL versus 3 h	0.085	6F	At 3 h: WT versus DRD5KO	0.012
	DRD5KO: BL versus 24 h	>0.99		At 24 h: WT versus DRD5KO	>0.99
	DRD5KO: BL versus 48 h	>0.99		WT: D9 versus 3 h	0.0007