Table 1.

Characteristics of Tc in wild-type and Trpm8−/− mice exposed to different environmental temperaturesa

ParameterGenotype29°C21°C17°C
MESOR (°C)WT36.4 ± 0.0036.4 ± 0.136.3 ± 0.1
Trpm8−/−36.5 ± 0.0536.2 ± 0.0535.6 ± 0.1***,###
(p = 0.000004 vs 29 °C)
(p = 0.0005 vs 21 °C)
Amplitude (°C)WT0.6 ± 0.000.8 ± 0.00**0.9 ± 0.1***
(p = 0.001)(p = 0.0002)
Trpm8−/−0.6 ± 0.040.9 ± 0.03***0.8 ± 0.1*
(p = 0.00009)(p = 0.010)
  • aMESOR and amplitude of Tc in WT and Trpm8−/− male mice exposed to different environmental temperatures for 5–7 d. Tc values were adjusted to a sinusoidal function, as described by Cornelissen (2014). Data are mean ± SEM. Mice were males of 3–5 months of age.

  • *p < 0.05 (vs 29°C);

  • **p < 0.01 (vs 29°C);

  • ***p < 0.001 (vs 29°C).

  • ###p < 0.001 (21°C vs 17°C); repeated-measures ANOVA and Bonferroni test. WT: 29°C, n = 13; 21°C, n = 14; 17°C, n = 11. KO: 29°C, n = 12; 21°C, n = 14; 17°C, n = 13.