Compiled results of the behavioral tests on 52-week-old wild-type and Col13a1−/− mice
| Test type | Test | Gender | Col13a1+/+ (N = 6 or 7) (mean ± SEM) | Col13a1−/− (N = 6 or 7) (mean ± SEM) | p |
|---|---|---|---|---|---|
| Motor test | Grid hanging | Female | 300.0 ± 0.0 | 164.0 ± 38.2 | 0.021* |
| Time (s) | Male | 300.0 ± 0.0 | 76.7 ± 21.6 | 0.002** | |
| Rotarod | Female | 300.9 ± 20.0 | 300.6 ± 48.0 | 0.996 | |
| Time (s) | Male | 283.7 ± 62.6 | 230.2 ± 49.7 | 0.394 | |
| Beam walking | Female | 21.4 ± 11.3 | 14.6 ± 3.2 | 0.935 | |
| Time (s) | Male | 18.8 ± 4.7 | 22.8 ± 10.9 | 0.797 | |
| Beam walking | Female | 5.7 ± 1.3 | 8.0 ± 1.3 | 0.249 | |
| Slips (no.) | Male | 3.5 ± 1.1 | 9.8 ± 0.9 | 0.001*** | |
| Anxiety | Plus maze | Female | 10.6 ± 1.4 | 8.3 ± 2.1 | 0.377 |
| Movement | Visits closed arms (no.) | Male | 13.8 ± 2.0 | 12.3 ± 1.2 | 0.531 |
| Plus maze | Female | 0.4 ± 0.3 | 1.6 ± 0.6 | 0.176 | |
| Visits open arms (no.) | Male | 1.7 ± 0.6 | 1.0 ± 0.6 | 0.314 | |
| Plus maze | Female | 11.0 ± 1.6 | 9.9 ± 1.7 | 0.626 | |
| Total visits (no.) | Male | 15.5 ± 2.4 | 13.3 ± 1.1 | 0.431 | |
| Plus maze | Female | 4.6 ± 0.1 | 3.1 ± 0.7 | 0.005** | |
| Time closed arms (min) | Male | 3.7 ± 0.3 | 3.9 ± 0.4 | 0.255 | |
| Plus maze | Female | 0.04 ± 0.03 | 1.8 ± 0.6 | 0.103 | |
| Time open arms (min) | Male | 0.2 ± 0.1 | 0.2 ± 0.2 | 0.260 | |
| Anxiety | Marble burying | Female | 6.1 ± 1.4 | 7.6 ± 1.0 | 0.413 |
| Marbles visible (no.) | Male | 3.0 ± 0.6 | 6.0 ± 1.1 | 0.036* | |
| Somatosensory | von Frey hairs | Female | 3.8 ± 0.4 | 4.8 ± 0.3 | 0.029* |
| Force (g) | Male | 3.5 ± 0.3 | 3.9 ± 0.5 | 0.471 | |
| Hot plate 47°C | Female | 50.0 ± 2.5 | 42.1 ± 4.0 | 0.118 | |
| Time (s) | Male | 37.5 ± 2.4 | 36.8 ± 4.9 | 0.905 | |
| Hot plate 51°C | Female | 15.7 ± 1.0 | 15.7 ± 1.0 | 1.000 | |
| Time (s) | Male | 10.5 ± 0.5 | 12.3 ± 0.7 | 0.062 |