Table 4.

Descriptive statistics for clusters showing significant relationships between Ce functional connectivity and AT-related brain metabolism

HemisphereClusterVolume (mm3)Local maximatMaxapLocation (mm from AC)
RightAnterior cingulate5.86Area 24a, genu of the corpus callosum3.070.00111.875−10.6255.625
LeftBrainstem31.49Periaqueductal gray3.060.0012−2.50014.375−0.625
RightThalamus3.17Ventral anterior nucleus2.880.00212.5003.125−1.875
RightBrainstem16.85Reticular formation, precuneiform2.830.00253.75015.625−5.000
LeftCerebellum1.95Deep cerebellar nuclei2.820.0025−5.62524.375−11.250
LeftHippocampus1.95Cornus ammonis2.820.0025−16.2508.125−8.750
RightBasal forebrain1.46Paraventricular nucleus, posterior medial BST2.640.00430.6252.5−3.750
  • aVoxelwise regression controlling for nuisance variation in mean-centered age, sex, and scanner site (p < 0.01, uncorrected, two-tailed, with no minimum cluster size). The regression was restricted to voxels where FDG metabolism was associated with higher levels of AT in our prior work (p < 0.05, whole-brain Šidák corrected, n = 592; A. S. Fox et al., 2015b).