Electrophysiological properties of neocortical layer 2/3 pyramidal cells in wild-type versus Scn1a+/− mutant mice
| Age group | Genotype | n | Age (d) | Intrinsic properties | Repetitive action potential discharge | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Firing frequency (Hz) | Spike frequency adaptation | ||||||||||
| Mice | Cells | Vm (mV) | Rm (MΩ) | Rheobase (pA) | Steady-state | Instantaneous | ISI1/ISI10 | ISI1/ISIn | |||
| P18–P21 | WT | 4 | 10 | 18.2 ± 0.2 | −71.5 ± 2.2 | 117 ± 11 | 138 ± 21 | 38.3 ± 2.1 | 115 ± 12 | 0.78 ± 0.02 | 0.53 ± 0.03 |
| Scn1a+/− | 4 | 10 | 18.5 ± 0.2 | −70.3 ± 2.7 | 126 ± 21 | 121 ± 14 | 39.3 ± 3.5 | 132 ± 30 | 0.82 ± 0.02 | 0.53 ± 0.06 | |
| P35–P56 | WT | 4 | 12 | 44.4 ± 0.7 | −74.9 ± 1.9 | 85 ± 14 | 269 ± 43 | 44.9 ± 2.8 | 190 ± 21 | 0.35 ± 0.04 | 0.30 ± 0.03 |
| Scn1a+/− | 5 | 14 | 42.4 ± 1.4 | −74.7 ± 2.7 | 89 ± 14 | 248 ± 23 | 40.8 ± 2.2 | 199 ± 22 | 0.32 ± 0.05 | 0.28 ± 0.04 | |