Monkey groups | Intact | M1 lesioned | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Untreated | Treated with anti-Nogo-A antibody | ||||||||||||
Monkey IDs | Mk-IC | Mk-IE | Mk-IR | Mk-IZ | Mk-BI | Mk-CE | Mk-DG | Mk-DI | Mk-GE | Mk-JU | Mk-RO | Mk-SL | Mk-VA |
Species | fasc | mul | fasc | fasc | fasc | fasc | fasc | fasc | fasc | fasc | fasc | fasc | fasc |
Gender | M | M | F | M | M | M | M | F | F | M | M | M | M |
Side of M1 hand lesion | — | — | — | — | L | L | L (R)c | L | L | R | L | L | L |
Total volume of the M1 lesion in gray matter, mm3 | 0 | 0 | 0 | 0 | 20.1 | 112.8 | 32.2 | 68.5 | 48.7 | 63 | 14 | 78.2 | 20 |
Degree of functional recovery from M1 lesion; total score, %a | — | — | — | — | 74 | 42 | 58 | 39 | 38 | 39 | 98 | 73 | 87 |
Degree of functional recovery, V slots | — | — | — | — | 94 | 59 | 69 | 71 | 57 | 46 | 100 | 77 | 87 |
Degree of functional recovery, H slots | — | — | — | — | 36 | 9 | 45 | 7 | 11 | 29 | 90 | 77 | 91 |
Age at time of lesion (sacrifice for control monkeys), rounded 0.5 year | 10 | 5.5 | 6 | 8 | 5 | 4.5 | 10 | 10 | 5 | 5 | 4 | 5.5 | 5.5 |
Time interval lesion; sacrifice, d | — | — | — | — | 265 | 385 | 212 | 187 | 210 | 310 | 222 | 265 | 366 |
Weight at time of lesion, kg | — | — | — | — | 5 | 3.8 | 8.6 | 3.8 | 2.8 | 3.6 | 3.2 | 4.6 | 4.9 |
Volume ibotenic acid, μl | — | — | — | — | 29.7 | 40 | 24 | 39.7 | 13 | 40 | 18 | 18 | 15.5 |
Duration of recovery, db | — | — | — | — | 35 | 113 | 30 | 42 | 8 | 70 | 30 | 58 | 20(120) |
M, Male; F, female; R, right; L, left; fasc, M. fascicularis; mul, M. mulatta.
↵aExpressed in percentages of postlesion total score at plateau divided by pre-lesion total score in the modified Brinkman board task: all slots. The next two lines are the degrees of functional recovery given separately for the vertical (V) and horizontal (H) slots. The next two lines are the degrees of functional recovery given separately for the V and H slots.
↵bTime interval (Fig. 1F) from the day of lesion to the beginning of postlesion plateau, as defined by Kaeser et al. (2011). For Mk-VA, there was a second plateau of recovery that occurred 120 d postlesion, possibly linked to the anti-Nogo-A antibody treatment in this animal (Wyss et al., 2013).
↵c158 d after the permanent lesion with infusion of ibotenic acid, corresponding to 58 d before euthanasia.