Table 3.

Network connectivity and excitabilitya

SpikesSeizures
Connectivity
    Uniform, 2σ2 = 10YesNo
    Uniform, 2σ2 = 15YesNo
    Uniform, 2σ2 = 20YesNo
    Uniform, 2σ2 = 25YesNo
    Uniform, 2σ2 = 30YesNo
    Small-world, p = 10YesNo
    Small-world, p = 20YesYes
    Small-world, p = 30YesNo
    Small-world, p = 40YesNo
    Small-world, p = 50YesNo
    Scale-free, λ = 2.0YesNo
    Scale-free, λ = 2.5YesNo
    Scale-free, λ = 3.0YesNo
    Scale-free, λ = 3.5YesNo
    Scale-free, λ = 4.0Yes
Spontaneous release probability
    1 × 10−5YesYes
    5 × 10−5YesYes
    1 × 10−4YesYes
    5 × 10−4YesYes
    1 × 10−3YesNo
  • aFor the connectivity table, spontaneous release probability per second = 0.05. For the spontaneous release probability table, connectivity = small-world, with 25% of connections long-distance. The term long-distance refers to connections to neurons that are >5 neurons away from the index neuron. Uniform connectivity, σ = SD of the Gaussian connectivity probability distribution, connectivity probability being the probability of connecting to a neuron at increasing distance from index neuron. Small-world connectivity, p = percentage of long-distance connections. Scale-free connectivity, λ = exponential in power law for scale-free networks. In scale-free networks, the probability P(k) that a node in the network has k connections to other nodes in the network follows a power law: P(k) ∼ k−λ. Five independent simulations were run for each of the listed configurations.