Table 9.

In silico PSP amplitudes (mV) and the effects of Kv models with different input resistance (R) and capacitance (C) combinations

Corresponding group R + COverall R + C
OVXOVX+EOVXOVX+EOVX 38% Kv block
GABA, 10 nS
    dcPSP14.11 ± 0.5116.77 ± 0.35
    In silico R + C only16.1216.6716.39
        +mh14.8716.4115.1716.1215.56
        +OSI14.2415.8514.5815.7315.02
        +CSI15.5316.4815.8016.2416.02
AMPA, 3 nS
    dcPSP14.55 ± 0.6216.57 ± 0.62
    In silico R + C only19.8722.9321.26
        +mh17.3221.8318.2820.4019.06
        +OSI17.1220.2218.1519.4318.83
        +CSI18.4321.7519.4420.6019.95