Table 6.

Functional analysis of the phagocytic microglia transcriptome reveals changes in apoptosis

Gene symbolFC Ph3hFC Ph24 hLocationEffect on apoptosis
PRDX11,12AutologousAnti-apoptotic
SIRT121,6AutologousAnti-apoptotic
SMO13,6AutologousAnti-apoptotic
SOD21,22AutologousAnti-apoptotic
SPHK14,41,6AutologousAnti-apoptotic
UBE2B1,41,5AutologousAnti-apoptotic
XRCC52,13,8AutologousAnti-apoptotic
PRNP1,81,3Auto/HeteroAnti-apoptotic
TGM25,54,5Auto/HeteroAnti-apoptotic
CNTF1,52,6HeterologousAnti-apoptotic
FGF24,23,7HeterologousAnti-apoptotic
FGF81,71,6HeterologousAnti-apoptotic
VEGFA4,51,8HeterologousAnti-apoptotic
RARG1,33AutologousPleiotropic
IL618,715,8HeterologousPleiotropic
BAD1,82,2AutologousProapoptotic
FAS1,51,5AutologousProapoptotic
FOXO32138AutologousProapoptotic
GAS12,73AutologousProapoptotic
NLRP31219AutologousProapoptotic
PPP2CB1,51,6AutologousProapoptotic
PTEN1,11,6AutologousProapoptotic
RHOA11,7AutologousProapoptotic
SCRIB1,92,4AutologousProapoptotic
STK311,5AutologousProapoptotic
TFPT2,43AutologousProapoptotic
GAL1,21,8HeterologousProapoptotic
IL1β8,930,7HeterologousProapoptotic
  • Classification of the genes related to cell death obtained from DAVID analysis. The genes were classified according to their FC, to the effects on microglia (autologous), or on the surrounding cells (heterologous) and to the positive or negative effect on apoptosis.