Supplementary statistical information supporting Figure 9a
| Behavioral test | Trial/event | Pclowt/wt | n | Pclowt/gt | n | Pclogt/gt | n | wt/wt versus wt/gt (df), t value, p value | wt/wt versus gt/gt (df), t value, p value | One-way ANOVA |
|---|---|---|---|---|---|---|---|---|---|---|
| Rotarod performance: | 1 | 26.75 ± 6.486 | 4 | 16.5 ± 8.431 | 4 | 3.25 ± 0.75 | 4 | (144), 0.681, >0.9999 | (144), 1.561, >0.9999 | |
| Time to fall (s) | 2 | 3 ± 9.138 | 4 | 38.75 ± 13.231 | 4 | 3.25 ± 0.479 | 4 | (144), 0.515, >0.9999 | (144), 1.843, >0.9999 | |
| 3 | 29 ± 12.748 | 4 | 26.75 ± 13.949 | 4 | 2.75 ± 0.25 | 4 | (144), 0.15, >0.9999 | (144), 1.744, >0.9999 | ||
| 4 | 35.25 ± 11.25 | 4 | 23 ± 11.979 | 4 | 3.25 ± 0.479 | 4 | (144), 0.814, >0.9999 | (144), 2.126, >0.9999 | ||
| 5 | 41.75 ± 10.053 | 4 | 38 ± 15.647 | 4 | 4.5 ± 1.041 | 4 | (144), 0.249, >0.9999 | (144), 2.474, 0.6963 | ||
| 6 | 56.25 ± 5.023 | 4 | 42.5 ± 13.531 | 4 | 3.5 ± 0.5 | 4 | (144), 0.1913, >0.9999 | (144), 3.504, 0.0293 | ||
| 7 | 50.75 ± 17.585 | 4 | 44 ± 6.205 | 4 | 4.5 ± 1.323 | 4 | (144), 0.45, >0.9999 | (144), 3.072, 0.122 | ||
| 8 | 65.25 ± 18.688 | 4 | 41.75 ± 11.048 | 4 | 4.5 ± 0.957 | 4 | (144), 1.561, >0.9999 | (144), 4.035, 0.0042 | ||
| 9 | 63.25 ± 16.163 | 4 | 61.5 ± 18.319 | 4 | 3.25 ± 0.75 | 4 | (144), 0.116, 0.0079 | (144), 3.986, 0.0051 | ||
| 10 | 84.5 ± 6.225 | 4 | 60.25 ± 18.396 | 4 | 2.5 ± 0.5 | 4 | (144), 1.611, 0.0089 | (144), 5.447, 0.0001 | ||
| 11 | 72 ± 5.339 | 4 | 76.75 ± 12.419 | 4 | 3 ± 0.408 | 4 | (144), 0.316, 0.001 | (144), 4.583, 0.0005 | ||
| 12 | 71 ± 6.178 | 4 | 68.75 ± 9.681 | 4 | 4 ± 0.707 | 4 | (144), 0.15, 0.0015 | (144), 4.451, 0.0008 | ||
| 13 | 59 ± 8.297 | 4 | 57.75 ± 12.99 | 4 | 2.5 ± 0.5 | 4 | (144), 0.083, 0.0164 | (144), 3.753, 0.0121 | ||
| 14 | 69.25 ± 12.479 | 4 | 61 ± 13.638 | 4 | 2.5 ± 0.645 | 4 | (144), 0.548, 0.0074 | (144), 4.434, 0.0009 | ||
| 15 | 60.5 ± 16.297 | 4 | 65 ± 18.757 | 4 | 1.75 ± 0.479 | 4 | (144), 0.3, 0.0022 | (144), 3.903, 0.0070 | ||
| 16 | 56.5 ± 16.775 | 4 | 68.75 ± 17.109 | 4 | 2.25 ± 0.25 | 4 | (144), 0.814,0.009 | (144), 3.604, 0.0207 | ||
| Grip strength task:force (g) | 737.2 ± 109.9 | 4 | 621.2 ± 93.46 | 4 | 757.5 ± 66.74 | 4 | F(2,9) = 0.642, p = 0.549 | |||
| Ladder walk: FL errors/step | 0.09 ± 0.00925 | 4 | 0.148 ± 0.0263 | 4 | 0.297 ± 0.0145 | 4 | #p = 0.0157 | **p = 0.002 | ||
| Ladder walk: HL errors/step | 0.0563 ± 0.0221 | 4 | 0.0663 ± 0.00877 | 4 | 0.238 ± 0.0543 | 4 | #p = 0.0186 | *p = 0.0135 | ||
| Open field task: total events | Cross | 178.3 ± 29.68 | 4 | 164.5 ± 45.51 | 4 | 235.5 ± 27.11 | 4 | p > 0.9999 | p = 0.8337 | F(2,9) = 1.154, p = 0.828 |
| Rear | 64.25 ± 18.31 | 4 | 76.25 ± 11.3 | 4 | 22 ± 4.203 | 4 | p > 0.9999 | p = 0.1277 | F(2,9) = 5.069, p = 0.0335 | |
| Groom | 2.75 ± 0.75 | 4 | 2 ± 1.08 | 4 | 5 ± 1.155 | 4 | p > 0.9999 | p = 0.4494 | F(2,9) = 2.388, p = 0.1473 | |
| Mean distance traveled | 135.7 ± 11.25 | 10 | 129.3 ± 10.44 | 4 | 217.8 ± 14.33 | 12 | p > 0.9999 | ***p = 0.0004 | ||
| Pull-task: force (success rate) | 30 g | 86.722 ± 2.3 | 10 | 84.374 ± 6.324 | 4 | 61.044 ± 5.928 | 11 | p > 0.9999 | **p = 0.0018 | |
| 40 g | 83.603 ± 2.86 | 10 | 85.136 ± 7.373 | 4 | 47.804 ± 6.897 | 10 | p > 0.9999 | ****p = 0.0001 | ||
| 50 g | 80.49 ± 3.442 | 10 | 71.93 ± 8.695 | 4 | 33.647 ± 6.802 | 10 | p > 0.9999 | ****p = 0.0001 | ||
| 60 g | 69.19 ± 4.99 | 10 | 70.409 ± 10.181 | 3 | 30.003 ± 11.359 | 4 | p > 0.9999 | ***p = 0.0004 | ||
↵aData are mean ± SEM, F, n, df, t, and p values for behavioral data as depicted in Figure 9.