Mouse cohorts used in study
| Control 1 month | 5xFAD 1 month | Control 3 months | 5xFAD 3 months | Control 1 month | 5xFAD 1 month | Control 3 months | 5xFAD 3 months | |
|---|---|---|---|---|---|---|---|---|
| nmice | 10 (6f) | 10 (4f) | 27 (17f) | 29 (12f) | 10 (2f) | 10 (6f) | 15 (7f) | 12 (8f) |
| Age (postnatal days) | 40.2 ± 4.4 | 40.4 ± 4.6 | 95.8 ± 6.0 | 94.5 ± 5.8 | 42.0 ± 5.2 | 43.8 ± 4.2 | 91.8 ± 5.2 | 92.5 ± 5.4 |
| nslice (range 2–8) | 5.6 ± 0.8 | 4.0 ± 1.8 | 3.9 ± 1.3 | 3.2 ± 1.4 | ||||
| % Slices with SWRs | 93.8 ± 8.1% | 70.8 ± 22.0% | 72.4 ± 19.8% | 66.3 ± 26.1% | ||||
| Thy1-GCaMP6f(Figs. 3–5) | PVCre-tdTom(Figs. 6–8) | Thy1-GCaMP6f; PVCre-tdTom(Figs. 4–8) | ||||||
| Control | 5xFAD | Control | 5xFAD | Control | 5xFAD | |||
| nmice | 10 (5f) | 11 (5f) | 13 (8f) | 11 (5f) | 4 (4f) | 7 (2f) | ||
| Age (postnatal days) | 95.0 ± 7.4 | 93.4 ± 3.2 | 96.8 ± 5.7 | 97.4 ± 6.0 | 94.8 ± 3.2 | 91.6 ± 2.1 | ||
| nslice (range 2–8) | 3.9 ± 1.1 | 2.8 ± 1.3 | 3.8 ± 1.5 | 4.9 ± 2.1 | 4.5 ± 1.3 | 3.6 ± 1.8 | ||
| % Slices with SWRs | 75.5 ± 20.2% | 67.9 ± 26.2% | 67.4 ± 20.5% | 68.2 ± 25.3% | 80.8 ± 16.4% | 60.7 ± 30.5% | ||
| ncell-attached | 39 (PC) | 39 (PC) | 13 (PV) | 18 (PV) | 11 (PV) | 5 (PC); 14 (PV) | ||
| nwhole-cell | 21 (PC) | 15 (PC) | 11 (PV) | 16 (PV) | 10 (PV) | 1 (PC); 13 (PV) | ||
Top, Electrophysiology/imaging cohorts were distinct from behavioral cohorts. For both experiments, mice were studied at an age of one and three months. Bottom, The three-month electrophysiology/imaging cohort consisted of three subcohorts with different reporter genes.