Sham lesioned | 6-OHDA lesioned | |||||
---|---|---|---|---|---|---|
Control | l-DOPA-off | l-DOPA-on | PD | Dyskinesia-off | Dyskinesia-on | |
GPe | ||||||
n, number of neurons m, number of mice | n = 82 m = 3 | n = 92 m = 4 | n = 87 m = 3 | n = 82 m = 4 | n = 93 m = 4 | n = 75 m = 4 |
Early excitation | ||||||
Duration (ms)a | 4.3 ± 2.3 | 4.0 ± 2.1 | 5.2 ± 6.4 | 4.4 ± 2.4 | 3.5 ± 3.0 | 4.1 ± 2.7 |
Amplitude (spikes)a | 90.0 ± 56.0 | 90.3 ± 58.7 | 95.7 ± 55.9 | 77.3 ± 49.8 | 68.2 ± 59.8 | 58.6 ± 50.0 |
Inhibition | ||||||
Duration (ms)a | 7.3 ± 3.6 | 8.0 ± 3.0 | 8.3 ± 2.3 | 7.9 ± 4.1 | 7.0 ± 6.2 | 7.1 ± 6.5 |
Amplitude (spikes)b | −45.0 ± 25.0 | −52.2 ± 24.0 | −50.3 ± 20.9 | −51.2 ± 35.2 | −39.2 ± 40.3 | −51.6 ± 49.5 |
Late excitation | ||||||
Duration (ms)b | 36.2 ± 32.4 | 43.0 ± 34.1 | 38.8 ± 26.4 | 64.1 ± 46.2 | 65.4 ± 52.5 | 11.3 ± 11.4,##,$$ |
Amplitude (spikes)b | 495.6 ± 483.6 | 571.1 ± 497.2 | 501.0 ± 379.0 | 786.9 ± 599.8 | 868.4 ± 865.7 | 159.9 ± 395.6,##,$$ |
SNr | ||||||
n, number of neurons m, number of mice | n = 56 m = 4 | n = 56 m = 4 | n = 47 m = 4 | n = 66 m = 4 | n = 66 m = 4 | n = 41 m = 4 |
Early excitation | ||||||
Duration (ms)a | 5.0 ± 3.1 | 4.4 ± 3.5 | 4.6 ± 3.3 | 4.5 ± 4.4 | 3.2 ± 4.2 | 3.4 ± 3.7 |
Amplitude (spikes)a | 92.4 ± 73.4 | 94.8 ± 110.7 | 92.8 ± 77.8 | 88.4 ± 94.8 | 64.5 ± 90.4 | 50.0 ± 60.2 |
Inhibition | ||||||
Duration (ms)b | 4.7 ± 4.5 | 5.1 ± 5.4 | 5.7 ± 4.6 | 2.3 ± 5.7 | 4.6 ± 7.7 | 13.0 ± 11.3##, $$ |
Amplitude (spikes)b | −26.3 ± 26.7 | −29.2 ± 30.4 | −32.1 ± 26.3 | −13.8 ± 36.8 | −28.8 ± 51.8 | −69.9 ± 63.8##, $$ |
Late excitation | ||||||
Duration (ms)a | 13.4 ± 10.5 | 15.7 ± 19.0 | 16.0 ± 16.1 | 11.3 ± 12.5 | 9.9 ± 7.5 | 5.9 ± 7.5 |
Amplitude (spikes)a | 215.2 ± 187.5 | 202.5 ± 226.5 | 209.9 ± 203.4 | 147.5 ± 148.4 | 126.8 ± 113.2 | 54.2 ± 69.7 |
Values are means ± SD, *p < 0.05, **p < 0.01 significantly different from the corresponding states of the sham-lesioned group, ##p < 0.01 significantly different from the PD state, $$p < 0.01 significantly different from the dyskinesia-off state; atwo-way ANOVA (no interaction between lesion group × l-DOPA treatment) followed by Bonferroni's post hoc test, btwo-way ANOVA (significant interaction between lesion group × l-DOPA treatment) followed by Kruskal–Wallis test with Dunn's multiple comparison test.