Table 1.

Open field activity of conditional D1R- and D2R-γ7 KO mice and WT littermatesa

MalesFemales
Vertical countsStereotypy%ThigmotaxisVertical countsStereotypy%Thigmotaxis
Gng7fl/fl1305 ± 12518671 ± 107966.5 ± 1.21214 ± 12414107 ± 90071.4 ± 1.8
Gng7fl/flD1Cre+1090 ± 9218463 ± 79967.6 ± 1.51127 ± 11214387 ± 96172.1 ± 2.1
Gng7fl/fl1080 ± 9418893 ± 98669.8 ± 1.21198 ± 10015872 ± 88872 ± 1.3
Gng7fl/flD2Cre+1809 ± 122***24966 ± 1227***71.1 ± 1.11940 ± 233**21084 ± 639***74.1 ± 1.2
  • aData are mean ± SEM; n = 14-21 mice/group. Average of cumulative vertical counts and stereotypic counts and % thigmotaxis (100* Σ distance peripherytot distance) over the 2 h testing period by male and female Gng7fl/flD1Cre+ mice, Gng7fl/flD2Cre+ mice, and relative littermate controls.

  • **p < 0.01,

  • ***p < 0.001, indicate significant difference between Gng7fl/flD2Cre+ mice and relative Gng7fl/fl WT littermates (Student's t test).