Brain regions that exhibited a reliable association between cognitive processing score from the NIH toolbox and brain signal variability measure during placebo and drug condition as well as drug-related change in brain signal variability in older adults alone
| Cluster number | MNI co-ordinates | Peak threshold (BSR) | Cluster size (in 2 mm voxels) | Cortical region label based on Harvard-Oxford cortical atlas | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| 1 | 18 | −40 | 4 | 10.224636 | 621 | (R) Cingulate gyrus (posterior division; includes parts of parahippocampal gyrus) |
| 2 | 20 | 4 | 0 | 9.2745419 | 1370 | (R) Pallidum |
| 3 | 12 | −46 | 62 | 8.2238169 | 4322 | (R) Postcentral gyrus (includes parts of left postcentral gyrus, and bilateral precentral gyrus, precuneus, lateral occipital cortex) |
| 4 | −52 | −28 | 28 | 7.7824106 | 2399 | (L) Supramarginal gyrus (anterior division; includes parts of Heschl's gyrus, central opercular cortex) |
| 5 | 30 | −72 | 38 | 7.6328068 | 510 | (R) Lateral occipital (superior division; includes parts of right superior parietal lobule) |
| 6 | 44 | −16 | −4 | 7.184948 | 387 | (R) Planum polare (includes parts of Heschl's gyrus, superior temporal gyrus) |
| 7 | 40 | 32 | 18 | 7.0990481 | 252 | (R) Middle Frontal Gyrus |
| 8 | 2 | 20 | 38 | 6.6304259 | 260 | Paracingulate gyrus (posterior division; includes parts of angular division of cingulate gyrus) |
| 9 | −58 | 10 | −2 | 6.3138566 | 260 | (L) Inferior temporal gyrus (pars opercularis) |
| 10 | 32 | 28 | 36 | 6.1835728 | 400 | (R) Middle frontal gyrus |
| 11 | −28 | 30 | −6 | 6.1152315 | 259 | (L) Frontal orbital cortex |
| 12 | −42 | −60 | 4 | 5.9749165 | 164 | (L) Lateral occipital cortex (inferior division) |
| 13 | −26 | 8 | −42 | 5.5768657 | 161 | (L) Temporal pole |
| 14 | −8 | 16 | 58 | 5.5280857 | 207 | (L) Superior frontal gyrus |
| 15 | 12 | 46 | −20 | 5.4033055 | 1406 | (R) Frontal pole |
| 16 | −36 | −12 | −24 | 5.3511524 | 234 | (L) Parahippocampal gyrus (anterior division; includes parts of temporal fusiform cortex) |
| 17 | −36 | 8 | 14 | 5.3335013 | 467 | (L) Central opercular cortex (includes parts of frontal operculum cortex) |
| 18 | 26 | 6 | −44 | 5.3303905 | 102 | (R) Temporal pole |
| 19 | 22 | 54 | 22 | 4.8249021 | 245 | (R) Frontal pole |
L = left hemisphere; R = right hemisphere.