Monte Carlo simulation parameters and sources in Figures 7 and 8
| Parameter | Value | Source |
|---|---|---|
| Glutamate diffusion constant (cm2·s−1) | 3 × 10−6 | Rusakov and Kullmann, 1998 |
| AMPAR parameters (glutamate) | ||
| k1 (m−1·s−1), k-1 (s−1) k-2 (s−1) γ0, δ0 (s−1) γ1, δ1 (s−1) γ2, δ2 (s−1) β, α (s−1) | 2 × 107, 9 × 103 0.41 1, 3 × 10−3 7.6, 1.8 × 103 35, 200 8 × 103, 3.1 × 103 | Robert and Howe, 2003 |
| Kynurenate | ||
| k3 (m−1·s−1) k-3 (s−1) | 5 × 107 9000 | Diamond and Jahr, 1997 |
| NMDAR parameters | ||
| on, off d1+, d1− d2+, d2− f+, f− s+, s− | 95 × 105, 29 0.5, 45 70, 2.8 1557, 182 89, 135 | Banke and Traynelis, 2003 |
| Mesh properties | ||
| Internal vesicle diameter (nm) Pore length (nm) Minimum pore diameter (nm) Synaptic cleft thickness (nm) Synaptic cleft diameter (nm) Thickness of cleft edge diffusion barrier (nm) | 25 8 0.4 20 300 1.7 | Hu et al., 2008 Vardjan et al., 2007 Savtchenko and Rusakov, 2007 Nimchinsky et al., 2002 Rusakov and Kullmann, 1998 |