Relative conductance values of the hPAC channel mutants
| Relative conductance values (mean ± SEM) | Patch numbers | Relative conductance values (mean ± SEM) | Patch numbers | ||
|---|---|---|---|---|---|
| WT | 6.5 ± 0.7 | 6 | E257Q | 2.3 ± 0.4 | 6 |
| D91N | 9.1 ± 3.0 | 6 | E257A | 1.8 ± 0.1 | 6 |
| E94Q | 10.8 ± 2.5 | 6 | E257C | 1.9 ± 0.1 | 6 |
| H98A | 7.2 ± 0.9 | 6 | E257D | 1.7 ± 0.2 | 6 |
| K106N | 6.5 ± 0.9 | 6 | R259Q | 4.7 ± 0.4 | 6 |
| E107Q | 5.9 ± 0.3 | 6 | E261Q | 6.5 ± 0.6 | 6 |
| V108A | 5.1 ± 1.0 | 6 | D269N | 10.4 ± 3.1 | 6 |
| E107A | 5.3 ± 0.4 | 6 | K288N | 3.9 ± 0.6 | 6 |
| E107C | 3.8 ± 0.3 | 6 | D289N | 1.6 ± 0.3 | 6 |
| E107R | 8.3 ± 1.4 | 6 | D289K | 2.1 ± 0.2 | 6 |
| D109N | 4.5 ± 0.6 | 6 | D289E | 2.8 ± 0.2 | 6 |
| D112N | 10.3 ± 1.6 | 6 | D289A | 1.9 ± 0.1 | 6 |
| H130/131A | 10.6 ± 1.2 | 6 | D297N | 9.7 ± 1.9 | 6 |
| E133Q | 10.5 ± 0.5 | 6 | P290A | 5.2 ± 0.5 | 6 |
| E176Q | 11.6 ± 2.7 | 6 | A81C | 2.3 ± 0.1 | 6 |
| R180Q | 5.0 ± 0.4 | 6 | A81C/E107Q | 2.8 ± 0.3 | 6 |
| E181Q | 11.1 ± 2.6 | 6 | A81C/E224Q | 2.3 ± 0.1 | 6 |
| D195N | 6.2 ± 1.8 | 6 | A81C/E257Q | 2.0 ± 0.2 | 6 |
| E209Q | 6.9 ± 1.7 | 6 | A81C/E261Q | 1.3 ± 0.1 | 6 |
| E224Q | 6.4 ± 0.9 | 6 | A81C/D289N | 2.0 ± 0.1 | 6 |
| K241N | 7.8 ± 0.7 | 6 | A81C/E107A | 3.7 ± 0.2 | 6 |
| E250Q | 4.6 ± 0.7 | 6 | E107A/D289N | 3.5 ± 0.3 | 6 |
| E254Q | 4.6 ± 0.8 | 6 | A81C/E107A/D289N | 1.8 ± 0.1 | 6 |
| V256A | 6.3 ± 0.6 | 6 | uninjected oocyte | 1.6 ± 0.1 | 6 |