Table 2.

NMDG-sensitive Na+ leak currents and NMDG-induced membrane potential changes in daytime and nighttime VIP+, NMS+, and GRP+ SCN neurons

INaL (pA/pF)ΔVm (mV)
DayVIP+2.1 ± 0.2
n = 46
−17.2 ± 0.7a
n = 25
NMS+1.9 ± 0.2
n = 38
−18.2 ± 0.9b
n = 23
GRP+1.9 ± 0.2
n = 19
−17.5 ± 0.8c
n = 20
NightVIP+1.8 ± 0.2
n = 42
−14.6 ± 0.6a
n = 27
NMS+1.8 ± 0.2
n = 33
−14.6 ± 0.8b
n = 19
GRP+1.7 ± 0.2
n = 23
−13.9 ± 0.7c
n = 23
  • Values are mean ± SEM; n = number of cells. INaL, NMDG-sensitive Na+ leak current density; ΔVm, NMDG-induced change in membrane potential.

  • a-cMean ΔVm values are different (a,bp < 0.05; cp < 0.01; Kolmogorov–Smirnov test) in daytime and nighttime VIP+(a), NMS+(b), and GRP+(c) SCN neurons. Mean daytime and nighttime INaL densities, in contrast, are similar in VIP+, NMS+, and GRP+ SCN neurons.