α-synuclein

Research Articles, Neurobiology of Disease
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Coeruleus Pathology and Nonmotor Features of Parkinson's Disease
Laura M. Butkovich, Madelyn C. Houser, Termpanit Chalermpalanupap, Kirsten A. Porter-Stransky, Alexa F. Iannitelli, Jake S. Boles, Grace M. Lloyd, Alexandra S. Coomes, Lori N. Eidson, Maria Elizabeth De Sousa Rodrigues, Danielle L. Oliver, Sean D. Kelly, Jianjun Chang, Nora Bengoa-Vergniory, Richard Wade-Martins, Benoit I. Giasson, Valerie Joers, David Weinshenker and Malú Gámez Tansey

Journal of Neuroscience 31 August 2020, 40 (39) 7559-7576; https://doi.org/10.1523/JNEUROSCI.1468-19.2020
Research Articles, Neurobiology of Disease
α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline
Winston T. Chu, Jesse C. DeSimone, Cara J. Riffe, Han Liu, Paramita Chakrabarty, Benoit I. Giasson, Vinata Vedam-Mai and David E. Vaillancourt

Journal of Neuroscience 15 July 2020, 40 (34) 6649-6659; https://doi.org/10.1523/JNEUROSCI.0189-20.2020
Research Articles, Neurobiology of Disease
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity
Gabriel E. Vázquez-Vélez, Kristyn A. Gonzales, Jean-Pierre Revelli, Carolyn J. Adamski, Fatemeh Alavi Naini, Aleksandar Bajić, Evelyn Craigen, Ronald Richman, Sabrina M. Heman-Ackah, Matthew J.A. Wood, Maxime W.C. Rousseaux and Huda Y. Zoghbi

Journal of Neuroscience 20 November 2019, 40 (2) 459-477; https://doi.org/10.1523/JNEUROSCI.1076-19.2019
Research Articles, Neurobiology of Disease
Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice
Molly M. Rajsombath, Alice Y. Nam, Maria Ericsson and Silke Nuber

Journal of Neuroscience 12 August 2019, 39 (38) 7628-7640; https://doi.org/10.1523/JNEUROSCI.0313-19.2019
Research Articles, Cellular/Molecular
α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons
Qihui Wu, Hajime Takano, Dawn M. Riddle, John Q. Trojanowski, Douglas A. Coulter and Virginia M.-Y. Lee

Journal of Neuroscience 29 April 2019, 39 (26) 5080-5094; https://doi.org/10.1523/JNEUROSCI.0060-19.2019
Cover ArticleResearch Articles, Neurobiology of Disease
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach
Maxime W.C. Rousseaux, Gabriel E. Vázquez-Vélez, Ismael Al-Ramahi, Hyun-Hwan Jeong, Aleksandar Bajić, Jean-Pierre Revelli, Hui Ye, Emily T. Phan, Jennifer M. Deger, Alma M. Perez, Ji-Yoen Kim, Laura A. Lavery, Qikia Xu, Mamie Z. Li, Hyojin Kang, Jean J. Kim, Joshua M. Shulman, Thomas F. Westbrook, Stephen J. Elledge, Zhandong Liu, Juan Botas and Huda Y. Zoghbi

Journal of Neuroscience 24 September 2018, 38 (43) 9286-9301; https://doi.org/10.1523/JNEUROSCI.0254-18.2018
Research Articles, Neurobiology of Disease
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein
Bing Wang, Rachel Underwood, Anjali Kamath, Colleen Britain, Michael B. McFerrin, Pamela J. McLean, Laura A. Volpicelli-Daley, Robert H. Whitaker, William J. Placzek, Katelyn Becker, Jiyan Ma and Talene A. Yacoubian

Journal of Neuroscience 9 August 2018, 38 (38) 8211-8232; https://doi.org/10.1523/JNEUROSCI.1134-18.2018
Research Articles, Neurobiology of Disease
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies
Edward Rockenstein, Gary Ostroff, Fusun Dikengil, Florentina Rus, Michael Mante, Jazmin Florio, Anthony Adame, Ivy Trinh, Changyoun Kim, Cassia Overk, Eliezer Masliah and Robert A. Rissman

Journal of Neuroscience 15 December 2017, 38 (4) 1000-1014; https://doi.org/10.1523/JNEUROSCI.1170-17.2017
Cover ArticleFeatured ArticleResearch Articles, Neurobiology of Disease
Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
Yumiko V. Taguchi, Jun Liu, Jiapeng Ruan, Joshua Pacheco, Xiaokui Zhang, Justin Abbasi, Joan Keutzer, Pramod K. Mistry and Sreeganga S. Chandra

Journal of Neuroscience 28 August 2017, 37 (40) 9617-9631; https://doi.org/10.1523/JNEUROSCI.1525-17.2017
Cover ArticleResearch Articles, Neurobiology of Disease
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies
Michael X. Henderson, Charlotte Hiu-Yan Chung, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Steven H. Seeholzer, John Q. Trojanowski and Virginia M.Y. Lee

Journal of Neuroscience 18 May 2017, 37 (24) 5870-5884; https://doi.org/10.1523/JNEUROSCI.2705-16.2017

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α-synuclein

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