Alzheimer's disease

Cover ArticleFeatured ArticleResearch Articles, Cellular/Molecular
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model
Qian Shi, Cheng Chang, Afaf Saliba and Manzoor A. Bhat

Journal of Neuroscience 7 June 2022, 42 (27) 5294-5313; https://doi.org/10.1523/JNEUROSCI.2427-21.2022
Research Articles, Neurobiology of Disease
Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration
Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern and Guey-Shin Wang

Journal of Neuroscience 23 May 2022, 42 (25) 5102-5114; https://doi.org/10.1523/JNEUROSCI.2006-21.2022
Review
The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders
Lili Zhang and Xiangyun Wei

Journal of Neuroscience 15 June 2022, 42 (24) 4774-4793; https://doi.org/10.1523/JNEUROSCI.0059-22.2022
Research Articles, Behavioral/Cognitive
Causal Evidence for the Multiple Demand Network in Change Detection: Auditory Mismatch Magnetoencephalography across Focal Neurodegenerative Diseases
Thomas E. Cope, Laura E. Hughes, Holly N. Phillips, Natalie E. Adams, Amirhossein Jafarian, David Nesbitt, Moataz Assem, Alexandra Woolgar, John Duncan and James B. Rowe

Journal of Neuroscience 8 March 2022, 42 (15) 3197-3215; https://doi.org/10.1523/JNEUROSCI.1622-21.2022
Research Articles, Neurobiology of Disease
Medial Temporal Lobe Networks in Alzheimer's Disease: Structural and Molecular Vulnerabilities
Robin de Flores, Sandhitsu R. Das, Long Xie, Laura E. M. Wisse, Xueying Lyu, Preya Shah, Paul A. Yushkevich and David A. Wolk

Journal of Neuroscience 27 January 2022, 42 (10) 2131-2141; https://doi.org/10.1523/JNEUROSCI.0949-21.2021
Research Articles, Neurobiology of Disease
Distinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults
Jenna N. Adams, Theresa M. Harrison, Anne Maass, Suzanne L. Baker and William J. Jagust

Journal of Neuroscience 29 December 2021, 42 (7) 1352-1361; https://doi.org/10.1523/JNEUROSCI.1601-21.2021
Research Articles, Neurobiology of Disease
Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease
Ece Kocagoncu, David Nesbitt, Tina Emery, Laura E. Hughes, Richard N. Henson, James B. Rowe and Cambridge Center for Ageing and Neuroscience

Journal of Neuroscience 10 January 2022, 42 (7) 1362-1373; https://doi.org/10.1523/JNEUROSCI.0697-21.2021
Research Articles, Neurobiology of Disease
Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease
Jie Cui, Ghania Ait-Ghezala, Kumar Sambamurti, Feng Gao, Yong Shen and Rena Li

Journal of Neuroscience 13 December 2021, 42 (6) 1154-1165; https://doi.org/10.1523/JNEUROSCI.0864-20.2021
Featured ArticleResearch Articles, Behavioral/Cognitive
Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults
Kaitlin B. Casaletto, Cutter A. Lindbergh, Anna VandeBunte, John Neuhaus, Julie A. Schneider, Aron S. Buchman, William G. Honer and David A. Bennett

Journal of Neuroscience 22 November 2021, 42 (2) 288-298; https://doi.org/10.1523/JNEUROSCI.1483-21.2021
Research Articles, Neurobiology of Disease
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
Masato Maesako, Mei C. Q. Houser, Yuliia Turchyna, Michael S. Wolfe and Oksana Berezovska

Journal of Neuroscience 22 November 2021, 42 (1) 145-154; https://doi.org/10.1523/JNEUROSCI.1698-21.2021

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Alzheimer's disease

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