amyloid precursor protein

Featured ArticleResearch Articles, Cellular/Molecular
Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons
Rodrigo S. Chaves, My Tran, Andrew R. Holder, Alexandra M. Balcer, Andrea M. Dickey, Elizabeth A. Roberts, Brian G. Bober, Edgar Gutierrez, Brian P. Head, Alex Groisman, Lawrence S.B. Goldstein, Angels Almenar-Queralt and Sameer B. Shah

Journal of Neuroscience 18 October 2021, 41 (49) 10034-10053; DOI: https://doi.org/10.1523/JNEUROSCI.2553-20.2021
Research Articles, Neurobiology of Disease
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model
Ramón Martínez-Mármol, Nika Mohannak, Lei Qian, Tong Wang, Rachel S. Gormal, Marc J. Ruitenberg, Bart Vanhaesebroeck, Elizabeth J. Coulson and Frédéric A. Meunier

Journal of Neuroscience 30 July 2019, 39 (40) 7976-7991; DOI: https://doi.org/10.1523/JNEUROSCI.0674-19.2019
Research Articles, Neurobiology of Disease
Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory
Walter Gulisano, Marcello Melone, Cristian Ripoli, Maria Rosaria Tropea, Domenica D. Li Puma, Salvatore Giunta, Sara Cocco, Daniele Marcotulli, Nicola Origlia, Agostino Palmeri, Ottavio Arancio, Fiorenzo Conti, Claudio Grassi and Daniela Puzzo

Journal of Neuroscience 24 May 2019, 39 (30) 5986-6000; DOI: https://doi.org/10.1523/JNEUROSCI.0163-19.2019
Research Articles, Neurobiology of Disease
Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP
Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones and Dominic M. Walsh

Journal of Neuroscience 3 November 2017, 37 (49) 11947-11966; DOI: https://doi.org/10.1523/JNEUROSCI.2009-17.2017
Cover ArticleResearch Articles, Cellular/Molecular
Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling
Abud Jose Farca Luna, Magali Perier and Laurent Seugnet

Journal of Neuroscience 17 March 2017, 37 (16) 4289-4300; DOI: https://doi.org/10.1523/JNEUROSCI.2826-16.2017
Articles, Neurobiology of Disease
APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease
Gunjan D. Manocha, Angela M. Floden, Keiko Rausch, Joshua A. Kulas, Brett A. McGregor, Lalida Rojanathammanee, Kelley R. Puig, Kendra L. Puig, Sanjib Karki, Michael R. Nichols, Diane C. Darland, James E. Porter and Colin K. Combs

Journal of Neuroscience 10 August 2016, 36 (32) 8471-8486; DOI: https://doi.org/10.1523/JNEUROSCI.4654-15.2016
Featured ArticleArticles, Neurobiology of Disease
Direct Transcriptional Effects of Apolipoprotein E
Veena Theendakara, Clare A. Peters-Libeu, Patricia Spilman, Karen S. Poksay, Dale E. Bredesen and Rammohan V. Rao

Journal of Neuroscience 20 January 2016, 36 (3) 685-700; DOI: https://doi.org/10.1523/JNEUROSCI.3562-15.2016
Featured ArticleArticles, Neurobiology of Disease
The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior
Maja Klevanski, Ulrike Herrmann, Sascha W. Weyer, Romain Fol, Nathalie Cartier, David P. Wolfer, John H. Caldwell, Martin Korte and Ulrike C. Müller

Journal of Neuroscience 9 December 2015, 35 (49) 16018-16033; DOI: https://doi.org/10.1523/JNEUROSCI.2009-15.2015
Articles, Neurobiology of Disease
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis
Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan and Jin-Moo Lee

Journal of Neuroscience 2 September 2015, 35 (35) 12137-12151; DOI: https://doi.org/10.1523/JNEUROSCI.0705-15.2015
Featured ArticleArticles, Neurobiology of Disease
The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons
Baiping Wang, Zilai Wang, Lu Sun, Li Yang, Hongmei Li, Allysa L. Cole, Jennifer Rodriguez-Rivera, Hui-Chen Lu and Hui Zheng

Journal of Neuroscience 1 October 2014, 34 (40) 13314-13325; DOI: https://doi.org/10.1523/JNEUROSCI.2848-14.2014

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