Down syndrome

Featured ArticleResearch Articles, Neurobiology of Disease
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M.C. Fisher and Frances K. Wiseman

Journal of Neuroscience 14 July 2022, 42 (33) 6453-6468; DOI: https://doi.org/10.1523/JNEUROSCI.0521-22.2022
Research Articles, Behavioral/Cognitive
Hyper-Rigid Phasic Organization of Hippocampal Activity But Normal Spatial Properties of CA1 Place Cells in the Ts65Dn Mouse Model of Down Syndrome
Robert G.K. Munn, Aimée Freeburn, David P. Finn and H. Craig Heller

Journal of Neuroscience 3 January 2022, 42 (8) 1542-1556; DOI: https://doi.org/10.1523/JNEUROSCI.2636-20.2021
Featured ArticleResearch Articles, Cellular/Molecular
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
Ying Jiang, Yutaka Sato, Eunju Im, Martin Berg, Matteo Bordi, Sandipkumar Darji, Asok Kumar, Panaiyur S. Mohan, Urmi Bandyopadhyay, Antonio Diaz, Ana Maria Cuervo and Ralph A. Nixon

Journal of Neuroscience 1 May 2019, 39 (27) 5255-5268; DOI: https://doi.org/10.1523/JNEUROSCI.0578-19.2019
Research Articles, Neurobiology of Disease
Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome
Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez and Josef Bischofberger

Journal of Neuroscience 18 April 2019, 39 (26) 5210-5221; DOI: https://doi.org/10.1523/JNEUROSCI.2723-18.2019
Research Articles, Neurobiology of Disease
Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome
Christopher M. William, Lubna Saqran, Matthew A. Stern, Charles L. Chiang, Scott P. Herrick, Aziz Rangwala, Mark W. Albers, Matthew P. Frosch and Bradley T. Hyman

Journal of Neuroscience 12 September 2017, 37 (41) 9880-9888; DOI: https://doi.org/10.1523/JNEUROSCI.1045-17.2017
Articles, Neurobiology of Disease
Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex
Marcel Ruiz-Mejias, Maria Martinez de Lagran, Maurizio Mattia, Patricia Castano-Prat, Lorena Perez-Mendez, Laura Ciria-Suarez, Thomas Gener, Belen Sancristobal, Jordi García-Ojalvo, Agnès Gruart, José M. Delgado-García, Maria V. Sanchez-Vives and Mara Dierssen

Journal of Neuroscience 30 March 2016, 36 (13) 3648-3659; DOI: https://doi.org/10.1523/JNEUROSCI.2517-15.2016
Symposium and Mini-Symposium
New Perspectives for the Rescue of Cognitive Disability in Down Syndrome
Renata Bartesaghi, Tarik F. Haydar, Jean Maurice Delabar, Mara Dierssen, Carmen Martínez-Cué and Diana W. Bianchi

Journal of Neuroscience 14 October 2015, 35 (41) 13843-13852; DOI: https://doi.org/10.1523/JNEUROSCI.2775-15.2015
Articles, Neurobiology of Disease
Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome
Jillian L. Shaw, Shixing Zhang and Karen T. Chang

Journal of Neuroscience 12 August 2015, 35 (32) 11374-11383; DOI: https://doi.org/10.1523/JNEUROSCI.1163-15.2015
Articles, Behavioral/Cognitive
Designer Receptors Enhance Memory in a Mouse Model of Down Syndrome
Ashley M. Fortress, Eric D. Hamlett, Elena M. Vazey, Gary Aston-Jones, Wayne A. Cass, Heather A. Boger and Ann-Charlotte E. Granholm

Journal of Neuroscience 28 January 2015, 35 (4) 1343-1353; DOI: https://doi.org/10.1523/JNEUROSCI.2658-14.2015
Articles, Neurobiology of Disease
Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a
Aurore Thomazeau, Olivier Lassalle, Jillian Iafrati, Benoit Souchet, Fayçal Guedj, Nathalie Janel, Pascale Chavis, Jean Delabar and Olivier J. Manzoni

Journal of Neuroscience 22 January 2014, 34 (4) 1138-1147; DOI: https://doi.org/10.1523/JNEUROSCI.2852-13.2014

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Down syndrome

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