Biochemical and Biophysical Research Communications
Regular ArticleImmunohistochemical Localization of D-Aspartate in the Rat Pineal Gland
References (33)
- et al.
Brain Res.
(1994) - et al.
Biochem. Biophys. Res. Commun.
(1986) - et al.
Life Sci.
(1990) - et al.
FEBS Lett.
(1993) - et al.
Brain Res. Bull.
(1991) - et al.
Brain Res.
(1978) - et al.
TINS
(1982) - et al.
Brain Res.
(1983) - et al.
Life Sci.
(1996) Science
(1969)
J. Neurochem.
J. Neurochem.
J. Neurochem.
Science
J. Neurochem.
Proc. Natl. Acad. Sci. USA
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2022, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :For example, d-serine (Ser) is known as a bioactive substance controlling neurotransmission as the co-agonist of the N-methyl-d-aspartate (NMDA) subtype of the glutamate receptors [3], and the functional relationships to long-term potentiation [4] and long-term depression [5] have been demonstrated. The localization of d-aspartic acid in the pineal gland [6], anterior pituitary gland [7], adrenal gland [8] and testis [9] and relevance to the production of hormones in those organs have also been indicated [10–13]. Recently, clinical studies showing the relationships between the d-amino acids and diseases are ongoing using the physiological fluids of the patients [14–17].
Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues
2015, Journal of Pharmaceutical and Biomedical AnalysisD-Aspartate-An important bioactive substance in mammals: A review from an analytical and biological point of view
2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :The d-Asp content in the adult rat pineal gland is very high (approx. 3.5 μmol/g wet tissue) with a D% of approx. 33% [3], but there are regional differences in d-Asp immunoreactivity. Specifically, intense immunoreactivity is observed in the distal (caudal) region of the gland, while little staining is visible in the proximal (rostral) region [41]. In addition, d-Asp is localized to the cytoplasm of pinealocytes, which constitute approx. 80% of the cells in this gland.
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