Regular ArticleThioredoxin Negatively Regulates p38 MAP Kinase Activation and IL-6 Production by Tumor Necrosis Factor-α
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The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease
2014, Free Radical Biology and MedicineCitation Excerpt :Thus, overexpression of Trx-1 may repress JNK activation by suppressing ASK1. The regulation of CHOP by Trx-1 may be due to Trx-1 suppressing the activity of p38MAPK [42]. Interestingly, induction of CHOP was reported to perturb the cellular redox state by depleting cellular glutathione [43].
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Corresponding author: Shu Hashimoto, First Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchikamimachi, Itabashi-ku, Tokyo 173-8610, Japan. Fax +81-3-3972-2893. E-mail:[email protected].