Full PapersNeuronal Expression of Regulatory Helix-Loop-Helix Factor Id2 Gene in Mouse
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Specification of cortical projection neurons: transcriptional mechanisms
2020, Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, Second EditionDifferential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis
2015, Gene Expression PatternsCitation Excerpt :They are involved in multiple physiological and pathological processes, acting on cell growth, differentiation, senescence and survival (Lasorella et al., 2014; Ling et al., 2014; Sikder et al., 2003; Yokota, 2001). The different Id genes play key roles in embryonic and adult neurogenesis by regulating quiescence and self-renewal of neural stem cells as well as neuronal differentiation (Aloia et al., 2015; Bai et al., 2007; Havrda et al., 2008; Jen et al., 1997; Jung et al., 2010; Lyden et al., 1999; Nam and Benezra, 2009; Neuman et al., 1993; Ohtaka-Maruyama et al., 2007). Given that expression patterns of Id proteins strongly overlap in various tissues, redundancy in their function has been suggested (Langlands et al., 1997; Sun et al., 1991).
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling
2011, Molecular and Cellular NeuroscienceCitation Excerpt :For example, Mafb and Stmn2 (cluster 2) are expressed in a peripheral cell layer in the OB in both E15 and E18 embryos (Fig. 4D and E). This pattern most likely corresponds expression in the mitral cell layer since Id2 is expressed here at this developmental stage (Neuman et al., 1993) (Fig. 4F). Three other genes from cluster 3, Nr2f1, Foxo1, and Heyl, are expressed in the olfactory nerve layer (Fig. 4G–I).
The inhibitor of DNA binding 2 is mainly expressed in oligodendrocyte lineage cells in adult rat brain
2007, Neuroscience LettersshRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development
2007, Cell Stem CellCitation Excerpt :Early stage forebrain progenitor cells are stimulated to divide and generate neurons by β-catenin signaling (Chenn and Walsh, 2002; Hirabayashi et al., 2004; Zechner et al., 2003; Shen et al., 2004). Id2 is normally expressed in ventricular zone cells at high levels, where it can inhibit bHLH differentiation pathways (Neuman et al., 1993), and Id2 can directly bind to Rb and inactivate it (Lasorella et al., 2005). These observations raise the hypothesis that Bmi-1-dependent regulation of p21-Rb pathway components alters NSC self-renewal properties at different stages of development.
Localization of Id2 mRNA in the adult mouse brain
2006, Brain Research