Full PapersMerosin Promotes Neurite Growth and Schwann Cell Migration in Vitro and Nerve Regeneration in Vivo: Evidence Using an Antibody to Merosin, ARM-1
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Retinoic acid regulates Schwann cell migration via NEDD9 induction by transcriptional and post-translational mechanisms
2016, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :After nerve injury, Schwann cells dedifferentiate, proliferate and migrate providing a guide for regenerating axons by interacting with nerve fibers or basal lamina [53]. SC migration is crucial for successful axonal elongation [53,54]. Migrating SCs organize themselves into cords spanning the two injured ends and the growth cones from the regenerating axons in the proximal stump will migrate along those bridges towards the distal end, where the bands of Büngner will guide these axons back to their targets [55–57].
Effect of carboxymethylated chitosan on the biosynthesis of NGF and activation of the Wnt/β-catenin signaling pathway in the proliferation of Schwann cells
2013, European Journal of PharmacologyCitation Excerpt :Schwann cells are a major source of neurotrophins, such as nerve growth factor (NGF), which play a critical role in response to nerve injury. There have been several reports indicating that Schwann cell proliferation is crucial for successful axonal elongation (Anton et al., 1994; Torigoe et al., 1996). Wnt/β-catenin signaling plays a major role in the development of the nervous system and contributes to neuronal plasticity.
Carboxymethylated chitosan stimulates proliferation of Schwann cells in vitro via the activation of the ERK and Akt signaling pathways
2011, European Journal of PharmacologyCitation Excerpt :SCs are a major source of neurotrophins, such as nerve growth factor (NGF), which plays a critical role in response to nerve injury. Many researchers reported that SCs proliferation is crucial for successful axonal elongation (Anton et al., 1994; Torigoe et al., 1996). In peripheral nerve repair, bridging large neural gaps with autologous nerve grafts remains the gold standard of therapy despite its inherent drawbacks that are difficult to overcome.
Transplantation of bone marrow stromal cells for peripheral nerve repair
2007, Experimental NeurologyModulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve
2006, Brain ResearchCitation Excerpt :Previous studies have shown different concentrations of some ECM molecules during peripheral nerve injury, particularly on the rat sciatic nerve (Siironen et al., 1996; Vogelezang et al., 1999). There is evidence that LN plays an important role on axon regeneration and myelination (Fernandez-Valle et al., 1993; Anton et al., 1994; Tonge et al., 1997; Podratz et al., 2001; Chen and Strickland, 2003). Some studies have analyzed specific LN molecules such as α1-chain, α2-chain, β1-chain and β2-chain after nerve crush or transection; these studies showed an increase on the expression of the LN isoforms on early events of nerve degeneration and regeneration (Doyu et al., 1993; Siironen et al., 1996).
Exercise, cognition and Alzheimer's disease: More is not necessarily better
2006, Neuroscience and Biobehavioral Reviews