Regular ArticlePressure-Induced Apoptosis in Human Lymphoblasts☆
References (19)
Exp. Cell Res.
(1963)- et al.
Int. Rev. Cytol.
(1980) - et al.
Exp. Cell Res.
(1964) - et al.
J. Cryst. Growth
(1997) - et al.
Biochim. Biophys. Acta
(1992) High Pressure Effects on Cellular Processes
(1970)- et al.
Nature
(1989) - et al.
Colloq. Iserm.
(1992) - et al.
Cytobios
(1973)
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Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth
2020, Seminars in Cancer BiologyCitation Excerpt :For instance a 10 min exposure to 0.5−0.7 MPa (1 MPa is equal to 10 times the atmospheric pressure) can trigger ganglion neuron cell death [47]. A 30 min exposure to 85–200 MPa is necessary to induce apoptosis 8 h later in lymphoblasts [48]. While those conditions are far away from the physiological pressure levels (several order of magnitudes more that the pressure observed in osteoblasts, 100–300 kPa [49]), they suggest that compression is sufficient to trigger cell death and that different cell types have differential sensitivity to compression, in agreement with the hypothesis described in the previous section.
Piezo channel plays a part in retinal ganglion cell damage
2020, Experimental Eye ResearchCitation Excerpt :Cells are exposed to various mechanical stimuli such as shear stress by blood flow, osmotic pressure, extension stress by touching or folding changes, and pressure stress by elevated IOP. In addition, excessive mechanical stress can lead to cell death (Quan et al., 2014; Takano et al., 1997). The transducers for the mechanical stresses are the mechanotransducers, and their signals are transmitted centrally.
Multiple Influences of Mechanical Forces on Cell Competition
2019, Current BiologyCitation Excerpt :An overload of mechanical stress can trigger cell elimination through either excessive stretching or excessive compression (Box 1). For instance, increasing hydrostatic pressure from 0.5 to 200 MPa (5 to 2,000 times the atmospheric pressure) is sufficient to trigger apoptosis and/or necrosis [63,64]. However, these pressures are one to three orders of magnitude higher than the pressure experienced by cells in vivo (e.g. 100–300 kPa for osteoblasts [65]).
Retinal ganglion cell line apoptosis induced by hydrostatic pressure
2006, Brain ResearchCitation Excerpt :Apoptosis in cortical neurons has been found in vivo in research into high pressure neurological syndrome and cerebral trauma (Mennel et al., 1997; Runnerstam et al., 2001). In vitro work linking hydrostatic pressure directly with induced apoptosis has been described in vascular endothelial and smooth muscle cells, lymphoblasts and leukemia cells (Galea et al., 1999; Takano et al., 1997; Take et al., 2001). However, very little is known regarding neuronal apoptosis and hydrostatic pressure as an isolated and independent stimulus.
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A. M. Zimmerman, Ed.
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To whom correspondence should be addressed at Institute of Materials Science, University of Tsukuba, Tsukuba, Ibaraki 305, Japan. Fax: (81)-298-55-7440. E-mail: [email protected].